HitPredict

Interactor 1: DHB4 (P51660)
Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]
Gene: Hsd17b4

Interactor 2: DHB4 (P51660)
Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]
Gene: Hsd17b4

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 29222160, 28130547
Identification Methods cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains adh_short~adh_short, MaoC_dehydratas~MaoC_dehydratas, MFE-2_hydrat-2_N~MaoC_dehydratas, MFE-2_hydrat-2_N~MFE-2_hydrat-2_N, SCP2~SCP2
Common GO terms GO:0000038 - very long-chain fatty acid metabolic process
GO:0003857 - (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
and 18 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 735
Mm

1 735
+ Hs
+ Dm
+ Ce
+ Hs
+ Ss
+ Ec
+ Mm
+ At
+ At
+ At
+ At
+ At
+ Dm
+ At
+ At
+ Dm
+ At

Service provided by Combinatics, Japan

Last updated: 11Aug2025