Protein: DHB4
Peroxisomal multifunctional enzyme type 2 (DmMFE-2) [Includes: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.119)]

Gene: DHB4, Mfe2
Organism: Drosophila melanogaster
Interactions: 209
UniProt ID: Q9VXJ0

Gene Ontology (top 5):
GO:0003857 - (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005777 - peroxisome
GO:0006635 - fatty acid beta-oxidation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1488259

DHB4
Peroxisomal multifunctional enzyme type 2

2

19

Small-scale

0.806

High

653055

HMOC
Homeotic protein ocelliless

2

2

High-throughput

0.594

High

197895

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

19

High-throughput

0.575

High

1486950

KLHDB
Kelch-like protein diablo

2

1

High-throughput

0.542

High

1478822

Q9VJY4
GH14707p

2

1

High-throughput

0.521

High

1484363

Q9VQL7
Fatty acid synthase

1

2

High-throughput

0.514

High

458811

PER
Period circadian protein

1

1

High-throughput

0.464

High

1485213

Q9VRV9
Importin N-terminal domain-containing protein

1

1

High-throughput

0.464

High

1019690

TRXR1
Thioredoxin reductase 1, mitochondrial

1

2

High-throughput

0.445

High

1261595

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.445

High

1480381

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

7

High-throughput

0.445

High

1480446

Q9VL70
HL08109p

1

1

High-throughput

0.445

High

477701

SUHW
Zinc finger protein su(Hw)

1

1

High-throughput

0.437

High

1377533

Q95RF6
LD34461p

1

1

High-throughput

0.437

High

1485641

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

47819

A0AQH0
Proteasome subunit beta

1

2

High-throughput

0.407

High

54113

A1Z892
1-Cys peroxiredoxin

1

3

High-throughput

0.407

High

57673

A1ZB71
Glutathione S transferase E6

1

1

High-throughput

0.407

High

90894

F10A1
Hsc70-interacting protein 1

1

5

High-throughput

0.407

High

121352

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.407

High

234806

O46067
Hypoxia up-regulated protein 1

1

1

High-throughput

0.407

High

356598

O97121
cystathionine gamma-lyase

1

1

High-throughput

0.407

High

426837

HP1
Heterochromatin protein 1

1

3

High-throughput

0.407

High

556805

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.407

High

561858

MODU
DNA-binding protein modulo

1

1

High-throughput

0.407

High

609502

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.407

High

611559

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.407

High

648975

ANXB9
Annexin B9

1

1

High-throughput

0.407

High

649144

ANX10
Annexin B10

1

1

High-throughput

0.407

High

652809

PSA71
Proteasome subunit alpha type-7-1

1

1

High-throughput

0.407

High

712448

CALR
Calreticulin

1

1

High-throughput

0.407

High

726502

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

821943

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.407

High

835229

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.407

High

856166

MOEH
Moesin/ezrin/radixin homolog 1

1

2

High-throughput

0.407

High

871720

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

3

High-throughput

0.407

High

875312

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

929605

PDI
Protein disulfide-isomerase

1

2

High-throughput

0.407

High

1052509

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.407

High

1176378

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

2

High-throughput

0.407

High

1176642

NLP
Nucleoplasmin-like protein

1

1

High-throughput

0.407

High

1176832

NCPR
NADPH--cytochrome P450 reductase

1

1

High-throughput

0.407

High

1191737

Q3YMU0
Protein disulfide-isomerase

1

1

High-throughput

0.407

High

1262204

Q7JVH6
LD24696p

1

4

High-throughput

0.407

High

1262894

Q7JX87
1-Cys peroxiredoxin

1

3

High-throughput

0.407

High

1264175

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.407

High

1264754

Q7K148
Proteasome subunit beta

1

2

High-throughput

0.407

High

1265875

Q7K3J0
T-complex protein 1 subunit theta

1

1

High-throughput

0.407

High

1267286

Q7KKI0
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.407

High

1321752

Q8MT58
Carnosine dipeptidase 2, isoform A

1

1

High-throughput

0.407

High

1343375

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.407

High

1344484

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.407

High

1374742

ACPM
Acyl carrier protein, mitochondrial

1

1

High-throughput

0.407

High

1464381

Q9V3V2
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1464634

Q9V3V9
Endonuclease G inhibitor, isoform A

1

1

High-throughput

0.407

High

1465084

THIO2
Thioredoxin-2

1

2

High-throughput

0.407

High

1465306

PDIA6
Protein disulfide-isomerase A6 homolog

1

2

High-throughput

0.407

High

1466111

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.407

High

1467777

Q9VAC4
GEO09167p1

1

1

High-throughput

0.407

High

1468100

Q9VAL7
Calnexin 99A, isoform A

1

1

High-throughput

0.407

High

1468693

Q9VAY2
Heat shock protein 83

1

2

High-throughput

0.407

High

1469551

Q9VBR6
RE74917p

1

1

High-throughput

0.407

High

1471015

Q9VD02
GH14779p

1

1

High-throughput

0.407

High

1472521

Q9VEB1
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

1472966

FLNA
Filamin-A

1

1

High-throughput

0.407

High

1474326

Q9VG31
Malic enzyme

1

1

High-throughput

0.407

High

1474449

Q9VG69
LP03547p

1

6

High-throughput

0.407

High

1474796

Q9VGK3
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1475787

Q9VH81
protein-serine/threonine phosphatase

1

3

High-throughput

0.407

High

1475980

TEBPH
Cytosolic Prostaglandin E synthase

1

1

High-throughput

0.407

High

1476901

Q9VHX4
LD24679p

1

4

High-throughput

0.407

High

1478382

Q9VJD4
LD24721p

1

3

High-throughput

0.407

High

1478511

Q9VJJ0
Proteasome subunit beta

1

3

High-throughput

0.407

High

1479330

Q9VKB0
threonine--tRNA ligase

1

2

High-throughput

0.407

High

1479942

Q9VKW5
Prolyl endopeptidase

1

2

High-throughput

0.407

High

1480522

FKB59
FK506-binding protein 59

1

2

High-throughput

0.407

High

1480555

Q9VL89
Methionine aminopeptidase 2

1

1

High-throughput

0.407

High

1480919

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

1482188

ITPA
Inosine triphosphate pyrophosphatase

1

1

High-throughput

0.407

High

1482357

Q9VN44
FI07923p

1

1

High-throughput

0.407

High

1482475

PSB4
Proteasome subunit beta type-4

1

6

High-throughput

0.407

High

1483085

Q9VP52
GH24315p

1

2

High-throughput

0.407

High

1483407

Q9VPN5
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.407

High

1483833

Q9VQ61
Aspartate aminotransferase

1

1

High-throughput

0.407

High

1484327

Q9VQL1
serine--tRNA ligase

1

4

High-throughput

0.407

High

1484838

Q9VRD6
NTF2-related export protein

1

1

High-throughput

0.407

High

1484971

Q9VRL1
GEO06356p1

1

1

High-throughput

0.407

High

1485049

Q9VRP2
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

1485687

Q9VSL2
Glutathione S transferase O3

1

1

High-throughput

0.407

High

1486340

Q9VTY2
Uncharacterized protein, isoform A

1

4

High-throughput

0.407

High

1486625

Q9VUC1
Hsc70Cb, isoform A

1

1

High-throughput

0.407

High

1487361

Q9VVL7
Dihydrolipoyl dehydrogenase

1

2

High-throughput

0.407

High

1487694

Q9VW70
FI21813p1

1

1

High-throughput

0.407

High

1488262

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.407

High

1488263

TXND5
Thioredoxin domain-containing protein 5 homolog

1

3

High-throughput

0.407

High

1488264

Q9VZI1
Transgelin

1

2

High-throughput

0.407

High

1488266

Q9W022
GEO01508p1

1

3

High-throughput

0.407

High

1488270

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.407

High

1488275

CISY
Probable citrate synthase, mitochondrial

1

2

High-throughput

0.407

High

1488276

WUHO
tRNA

1

2

High-throughput

0.407

High

1488278

Q9W478
RE43153p

1

1

High-throughput

0.407

High

1488280

PSB3
Proteasome subunit beta type-3

1

2

High-throughput

0.407

High

1488281

Q9XYZ9
Glutathione S transferase E12, isoform A

1

1

High-throughput

0.407

High

1488283

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.407

High

1488285

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.407

High

638674

MAM
Neurogenic protein mastermind

1

0

High-throughput

0.282

High

1463324

Q9V3D7
EG:BACR7A4.2 protein

1

0

High-throughput

0.265

Low

1479607

SPZ4
Protein spaetzle 4

1

0

High-throughput

0.265

Low

1485111

Q9VRQ2
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.265

Low

1469957

ATLAS
Atlastin

1

0

Small-scale

0.249

Low

1479532

ZUC
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

57894

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.232

Low

86605

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

146008

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.232

Low

195156

O16043
Anon1A4

1

0

High-throughput

0.232

Low

197539

SPS1
Inactive selenide, water dikinase-like protein

1

0

High-throughput

0.232

Low

234646

VINC
Vinculin

1

0

High-throughput

0.232

Low

304739

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

305285

TRMB
tRNA

1

0

High-throughput

0.232

Low

305747

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.232

Low

356468

O97102
Small ubiquitin-related modifier

1

0

High-throughput

0.232

Low

357399

O97428
Ciboulot, isoform A

1

0

High-throughput

0.232

Low

357631

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.232

Low

460199

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.232

Low

477065

NDKA
Nucleoside diphosphate kinase

1

0

High-throughput

0.232

Low

578178

ENO
Enolase

1

0

High-throughput

0.232

Low

633017

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.232

Low

682849

PROF
Profilin

1

0

High-throughput

0.232

Low

762663

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

0

High-throughput

0.232

Low

874735

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.232

Low

875498

KARG
Arginine kinase 1

1

0

High-throughput

0.232

Low

929087

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

0

High-throughput

0.232

Low

930249

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

1019952

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.232

Low

1031299

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.232

Low

1052302

HMGD
High mobility group protein D

1

0

High-throughput

0.232

Low

1070843

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

1173608

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.232

Low

1176767

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.232

Low

1260912

Q76NR6
Regucalcin

1

0

High-throughput

0.232

Low

1262689

Q7JWV7
Tetraspanin

1

0

High-throughput

0.232

Low

1263094

Q7JXC4
CG6459 protein

1

0

High-throughput

0.232

Low

1263185

SEELE
Protein seele

1

0

High-throughput

0.232

Low

1264575

Q7K110
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.232

Low

1265338

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

1268000

TERA
Transitional endoplasmic reticulum ATPase TER94

1

0

High-throughput

0.232

Low

1268125

Q7KN85
ATP-citrate synthase

1

0

High-throughput

0.232

Low

1268309

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.232

Low

1269523

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.232

Low

1303999

Q8INK3
Fatty acid-binding protein, muscle

1

0

High-throughput

0.232

Low

1305800

Q8IQZ7
FI19014p1

1

0

High-throughput

0.232

Low

1306195

Q8IRD3
Glutathione peroxidase

1

0

High-throughput

0.232

Low

1322011

Q8MYY7
RE44624p

1

0

High-throughput

0.232

Low

1343084

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

0

High-throughput

0.232

Low

1345323

Q8T0L3
E1 ubiquitin-activating enzyme

1

0

High-throughput

0.232

Low

1374625

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.232

Low

1377730

FAXC
Failed axon connections

1

0

High-throughput

0.232

Low

1427910

IF5A
Eukaryotic translation initiation factor 5A

1

0

High-throughput

0.232

Low

1440094

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.232

Low

1440213

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.232

Low

1440634

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.232

Low

1445480

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.232

Low

1445658

CP2B
Cardio acceleratory peptide 2b

1

0

High-throughput

0.232

Low

1463353

Q9V3D8
GH27579p

1

0

High-throughput

0.232

Low

1463720

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.232

Low

1464546

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.232

Low

1466291

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.232

Low

1467023

Q9V9U3
LD45254p

1

0

High-throughput

0.232

Low

1467682

Q9VAC1
GM14349p

1

0

High-throughput

0.232

Low

1468232

Q9VAN7
Phosphoglycerate mutase

1

0

High-throughput

0.232

Low

1469631

Q9VBT1
CHK kinase-like domain-containing protein

1

0

High-throughput

0.232

Low

1470550

Q9VCK6
LD34157p

1

0

High-throughput

0.232

Low

1471181

Q9VD29
small monomeric GTPase

1

0

High-throughput

0.232

Low

1474375

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

1475155

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.232

Low

1476317

Q9VHL2
T-complex protein 1 subunit eta

1

0

High-throughput

0.232

Low

1476502

Q9VHN7
transketolase

1

0

High-throughput

0.232

Low

1476646

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.232

Low

1477005

Q9VI04
Beta-ureidopropionase

1

0

High-throughput

0.232

Low

1477417

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.232

Low

1480101

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

0

High-throughput

0.232

Low

1480199

EF1D
Probable elongation factor 1-delta

1

0

High-throughput

0.232

Low

1480648

Q9VLB7
Rab GDP dissociation inhibitor

1

0

High-throughput

0.232

Low

1480857

AK200
A-kinase anchor protein 200

1

0

High-throughput

0.232

Low

1482011

Q9VMU6
LD31822p

1

0

High-throughput

0.232

Low

1482517

Q9VNB2
RE42193p

1

0

High-throughput

0.232

Low

1483704

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

1484149

BACC
Bacchus

1

0

High-throughput

0.232

Low

1486478

Q9VU35
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.232

Low

1486797

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.232

Low

1487191

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.232

Low

1487664

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.232

Low

1487837

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.232

Low

1487991

Q9VWQ7
Coactosin-like protein

1

0

High-throughput

0.232

Low

1488260

Q9VXQ3
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.232

Low

1488261

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

0

High-throughput

0.232

Low

1488265

Q9VZY0
LD45195p

1

0

High-throughput

0.232

Low

1488267

Q9W0E4
Aminopeptidase

1

0

High-throughput

0.232

Low

1488268

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.232

Low

1488269

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.232

Low

1488271

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

0

High-throughput

0.232

Low

1488272

Q9W3F6
Bleomycin hydrolase

1

0

High-throughput

0.232

Low

1488273

Q9W3X6
fumarate hydratase

1

0

High-throughput

0.232

Low

1488274

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.232

Low

1488277

Q9W457
Serine hydroxymethyltransferase

1

0

High-throughput

0.232

Low

1488279

NSUN2
tRNA

1

0

High-throughput

0.232

Low

1488282

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.232

Low

1488284

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025