HitPredict

Interactor 1: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Interactor 2: PP12C (Q9BZL4)
Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85)
Gene: PPP1R12C

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	26496610, 27880917, 28330616
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 327 Hs			1 782
+	Hs
		906116 PP1A_HUMAN (1-326): 0: 576: 88.79		PP12C_HUMAN (1-782): 1.36e-154: 471: 100.00
+	Mm
		906252 PP1A_MOUSE (1-326): 0: 576: 88.49		PP12C_MOUSE (19-782): 1.24e-138: 429: 85.92
+	Hs
		906561 PP1B_HUMAN (1-327): 0: 597: 100.00		PP16A_HUMAN (13-478): 5.8e-85: 281: 29.56
+	Hs
		906079 PP1A_HUMAN (1-326): 0: 576: 88.79		PP16A_HUMAN (13-478): 5.8e-85: 281: 29.56
+	Hs
		906572 PP1B_HUMAN (1-327): 0: 597: 100.00		PP16B_HUMAN (12-545): 6.28e-69: 239: 23.19
+	Hs
		906146 PP1A_HUMAN (1-326): 0: 576: 88.79		TANC2_HUMAN (4-720): 4.19e-69: 250: 16.47
+	Ce
		953872 GLC7A_CAEEL (3-317): 0: 569: 92.38		P90902_CAEEL (31-441): 1.21e-73: 249: 26.45
+	Hs
		906099 PP1A_HUMAN (1-326): 0: 576: 88.79		PP16B_HUMAN (12-545): 6.28e-69: 239: 23.19
+	Hs
		3260 PP1B_HUMAN (1-327): 0: 597: 100.00		A0A0S2Z4Q8_HUMAN (12-191): 1.32e-41: 152: 49.74
+	Hs
		225133 PP1B_HUMAN (1-327): 0: 597: 100.00		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Gg
		907234 PP1B_CHICK (1-327): 0: 597: 100.00		MYPT1_CHICK (10-232): 1.66e-24: 112: 16.54
+	Hs
		161348 PP1B_HUMAN (1-327): 0: 597: 100.00		MYPT1_HUMAN (542-782): 1.47e-22: 105: 33.61
+	Mm
		906293 PP1A_MOUSE (1-326): 0: 576: 88.49		MYPT2_MOUSE (298-782): 1.34e-28: 125: 23.16
+	Hs
		225132 PP1A_HUMAN (1-326): 0: 576: 88.79		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Hs
		905838 PP1A_HUMAN (1-326): 0: 576: 88.79		ANK2_HUMAN (192-510): 1.07e-25: 116: 13.86
+	Hs
		161347 PP1A_HUMAN (1-326): 0: 576: 88.79		MYPT1_HUMAN (542-782): 1.47e-22: 105: 33.61
+	Mm
		906366 PP1A_MOUSE (1-326): 0: 576: 88.49		MYPT1_MOUSE (542-782): 3.39e-21: 101: 32.78
+	Mm
		926555 PP1G_MOUSE (1-327): 0: 569: 86.89		MYPT1_MOUSE (542-782): 3.39e-21: 101: 32.78
+	Hs
		906517 PP1B_HUMAN (1-327): 0: 597: 100.00		PPR27_HUMAN (223-309): 1.62e-09: 59.3: 40.23
+	Hs
		906000 PP1A_HUMAN (1-326): 0: 576: 88.79		PPR27_HUMAN (223-309): 1.62e-09: 59.3: 40.23