Protein: KLH21
Kelch-like protein 21

Gene: KLH21, KLHL21
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q9UJP4

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005827 - polar microtubule
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0031463 - Cul3-RING ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114601

CUL3
Cullin-3

10

20

Small-scale

0.972

High

1454625

KLHL9
Kelch-like protein 9

4

19

Small-scale

0.875

High

1386476

KLH29
Kelch-like protein 29

3

19

High-throughput

0.861

High

1452116

KLH28
Kelch-like protein 28

2

19

High-throughput

0.811

High

1454749

KLH13
Kelch-like protein 13

2

19

Small-scale

0.737

High

1335959

ZBT44
Zinc finger and BTB domain-containing protein 44

2

20

High-throughput

0.705

High

1419361

BACH2
Transcription regulator protein BACH2

1

20

High-throughput

0.691

High

1454583

KLH14
Kelch-like protein 14

1

20

High-throughput

0.691

High

482977

TPM1
Tropomyosin alpha-1 chain

3

1

High-throughput

0.667

High

1335870

ZBT34
Zinc finger and BTB domain-containing protein 34

1

12

High-throughput

0.618

High

1434619

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

20

High-throughput

0.618

High

1242707

KLC3
Kinesin light chain 3

2

2

High-throughput

0.606

High

877790

TNNI2
Troponin I, fast skeletal muscle

2

0

High-throughput

0.602

High

1152290

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

Small-scale

0.578

High

1391835

AURKB
Aurora kinase B

1

7

Small-scale

0.578

High

654143

XPA
DNA repair protein complementing XP-A cells

2

0

High-throughput

0.576

High

1199053

KLH12
Kelch-like protein 12

1

19

High-throughput

0.575

High

1247817

KLH24
Kelch-like protein 24

1

19

High-throughput

0.575

High

1459084

FXL17
F-box/LRR-repeat protein 17

1

16

High-throughput

0.575

High

1460612

KLH20
Kelch-like protein 20

1

19

High-throughput

0.575

High

1460614

IPP
Actin-binding protein IPP

1

19

High-throughput

0.575

High

167991

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

9

Small-scale

0.561

High

1446997

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

Small-scale

0.561

High

569281

YJU2B
Probable splicing factor YJU2B

2

1

High-throughput

0.549

High

725164

HXC9
Homeobox protein Hox-C9

2

3

High-throughput

0.549

High

51122

PKHG3
Pleckstrin homology domain-containing family G member 3

1

8

High-throughput

0.536

High

703253

HXD10
Homeobox protein Hox-D10

1

3

High-throughput

0.536

High

725004

HXA9
Homeobox protein Hox-A9

1

2

High-throughput

0.536

High

889353

NUMB
Protein numb homolog

1

5

High-throughput

0.536

High

909226

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.536

High

1243066

PKN3
Serine/threonine-protein kinase N3

1

6

High-throughput

0.536

High

1370446

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.536

High

1200025

KLH26
Kelch-like protein 26

1

20

High-throughput

0.514

High

860047

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

725171

HXC12
Homeobox protein Hox-C12

1

3

High-throughput

0.489

High

1101701

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

1394360

ZN414
Zinc finger protein 414

1

3

High-throughput

0.489

High

1395191

ZN462
Zinc finger protein 462

1

1

High-throughput

0.489

High

1460611

ZN777
Zinc finger protein 777

1

1

High-throughput

0.489

High

177957

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

10

Small-scale

0.479

High

920342

PLK1
Serine/threonine-protein kinase PLK1

1

5

Small-scale

0.479

High

1026581

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1309501

CEP97
Centrosomal protein of 97 kDa

1

6

Small-scale

0.479

High

1397535

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1460615

NEMO
NF-kappa-B essential modulator

1

6

Small-scale

0.479

High

1391972

DCNL1
DCN1-like protein 1

1

10

High-throughput

0.445

High

1437937

SP110
Sp110 nuclear body protein

1

5

High-throughput

0.437

High

1204719

TAF7L
Transcription initiation factor TFIID subunit 7-like

1

0

High-throughput

0.426

High

1231581

TBC3G
TBC1 domain family member 3G

1

1

High-throughput

0.407

High

171938

ZN263
Zinc finger protein 263

2

0

High-throughput

0.328

High

517834

GLI4
Zinc finger protein GLI4

1

0

High-throughput

0.279

Low

1460613

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025