HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	9452471, 35271311, 14743216
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 1512
+	Hs
		909585 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KPCD1_HUMAN (852-1510): 2.29e-124: 413: 16.89
+	Hs
		909621 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MYLK3_HUMAN (792-1510): 2.74e-124: 410: 15.35
+	Hs
		397155 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KPCG_HUMAN (899-1509): 4.13e-124: 405: 16.04
+	Zm
		45993 B6SRI4_MAIZE (4-255): 1.29e-145: 409: 70.47		A0A1Q0ZG94_MAIZE (840-1510): 2.6e-121: 413: 18.54
+	Hs
		166549 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DCLK1_HUMAN (996-1511): 1.41e-117: 389: 15.27
+	Hs
		909811 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DCLK2_HUMAN (996-1508): 3.42e-114: 380: 16.03
+	Mm
		910345 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		DCLK1_MOUSE (996-1511): 2.86e-114: 380: 15.04
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (1220-1512): 1.06e-122: 394: 23.81
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (1220-1512): 1.06e-122: 394: 23.81
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (1220-1512): 1.06e-122: 394: 23.81
+	At
		965291 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CDPK1_ARATH (1094-1509): 4.85e-119: 389: 20.99
+	At
		802001 14334_ARATH (4-255): 2.51e-145: 408: 73.62		CDPK1_ARATH (1094-1509): 4.85e-119: 389: 20.99
+	At
		788694 14335_ARATH (2-255): 3.04e-141: 398: 68.75		CDPK1_ARATH (1094-1509): 4.85e-119: 389: 20.99
+	Hs
		909447 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK3_HUMAN (1243-1510): 4.87e-105: 338: 27.21
+	Hs
		625306 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	At
		788620 14333_ARATH (1-253): 3.45e-147: 413: 74.12		M3K2_ARATH (1243-1506): 5.21e-59: 218: 43.61
+	Hs
		909957 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Hs
		910191 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K2_HUMAN (1238-1505): 3.52e-50: 191: 42.13
+	Hs
		909709 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K15_HUMAN (1249-1509): 4.63e-42: 171: 36.84
+	Hs
		909955 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K5_HUMAN (1249-1503): 1.95e-40: 166: 37.31