HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: SYDE1 (Q6ZW31)
Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1)
Gene: SYDE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 735
+	Hs
		909659 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SYDE2_HUMAN (93-713): 8.07e-98: 329: 38.25
+	Hs
		909650 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		RHG21_HUMAN (10-703): 9.42e-90: 310: 14.71
+	Hs
		506563 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		BCR_HUMAN (1-598): 7.89e-90: 308: 21.94
+	Hs
		909743 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SRGP1_HUMAN (117-733): 2.27e-90: 307: 13.66
+	Mm
		910322 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		SRGP2_MOUSE (114-734): 3.21e-88: 301: 12.74
+	Hs
		253335 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SRGP2_HUMAN (114-734): 6.4e-87: 297: 12.74
+	Mm
		910285 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		SRGP3_MOUSE (94-732): 2.87e-83: 288: 13.34
+	Hs
		70666 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MYO9A_HUMAN (7-728): 5.7e-78: 276: 15.46
+	Mm
		910284 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		RHG33_MOUSE (281-633): 8.07e-71: 254: 20.22
+	Hs
		64684 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		RHG32_HUMAN (281-651): 6.17e-66: 240: 20.90
+	Hs
		909873 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HMHA1_HUMAN (410-597): 1.75e-19: 95.9: 36.06