Protein: LHX3
LIM/homeobox protein Lhx3 (LIM homeobox protein 3)

Gene: LHX3
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q9UBR4

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1199146

LDB1
LIM domain-binding protein 1

4

20

High-throughput

0.902

High

1283500

ISL2
Insulin gene enhancer protein ISL-2

3

19

Small-scale

0.866

High

678980

HXC8
Homeobox protein Hox-C8

2

15

High-throughput

0.783

High

960062

HXC5
Homeobox protein Hox-C5

2

15

High-throughput

0.783

High

1137115

ANR45
Ankyrin repeat domain-containing protein 45

2

1

High-throughput

0.783

High

1144801

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

20

High-throughput

0.783

High

1163323

FIGLA
Factor in the germline alpha

2

14

High-throughput

0.783

High

1246575

IKBD
NF-kappa-B inhibitor delta

2

5

High-throughput

0.783

High

1255791

LMX1A
LIM homeobox transcription factor 1-alpha

1

18

Small-scale

0.724

High

1218454

TEX14
Inactive serine/threonine-protein kinase TEX14

2

7

High-throughput

0.700

High

632939

TYY1
Transcriptional repressor protein YY1

3

14

High-throughput

0.653

High

993635

TLE5
TLE family member 5

3

10

High-throughput

0.653

High

822689

LHX1
LIM/homeobox protein Lhx1

1

18

Small-scale

0.647

High

899935

ISL1
Insulin gene enhancer protein ISL-1

1

19

Small-scale

0.647

High

1314659

SSBP4
Single-stranded DNA-binding protein 4

2

20

High-throughput

0.628

High

1314910

SSBP3
Single-stranded DNA-binding protein 3

2

20

High-throughput

0.628

High

764711

CUX1
Homeobox protein cut-like 1

1

18

High-throughput

0.618

High

837771

MNX1
Motor neuron and pancreas homeobox protein 1

1

20

High-throughput

0.618

High

1059600

MEF2D
Myocyte-specific enhancer factor 2D

1

3

High-throughput

0.618

High

1167334

BCOR
BCL-6 corepressor

1

12

High-throughput

0.618

High

1199935

ZFHX4
Zinc finger homeobox protein 4

1

12

High-throughput

0.618

High

1218730

MGAP
MAX gene-associated protein

1

7

High-throughput

0.618

High

1281195

LHX4
LIM/homeobox protein Lhx4

1

19

Small-scale

0.618

High

1296429

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

14

High-throughput

0.618

High

1334137

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

12

High-throughput

0.618

High

1354245

TRPS1
Zinc finger transcription factor Trps1

1

19

High-throughput

0.618

High

1354247

SIX4
Homeobox protein SIX4

1

10

High-throughput

0.618

High

1354250

ZHX1
Zinc fingers and homeoboxes protein 1

1

20

High-throughput

0.618

High

1354253

SATB2
DNA-binding protein SATB2

1

7

High-throughput

0.618

High

1354256

ZHX2
Zinc fingers and homeoboxes protein 2

1

16

High-throughput

0.618

High

474068

UBFL1
Upstream-binding factor 1-like protein 1

2

17

High-throughput

0.606

High

594650

PSB1
Proteasome subunit beta type-1

2

1

High-throughput

0.606

High

735114

ZNF76
Zinc finger protein 76

2

10

High-throughput

0.606

High

800954

MK09
Mitogen-activated protein kinase 9

2

5

High-throughput

0.606

High

934537

CSK21
Casein kinase II subunit alpha

2

7

High-throughput

0.606

High

960127

CDK3
Cyclin-dependent kinase 3

2

3

High-throughput

0.606

High

987480

MTG8
Protein CBFA2T1

2

4

High-throughput

0.606

High

1012376

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

1048571

VEZF1
Vascular endothelial zinc finger 1

2

6

High-throughput

0.606

High

1085288

NRF1
Nuclear respiratory factor 1

2

4

High-throughput

0.606

High

1102965

QRIC1
Transcriptional regulator QRICH1

2

19

High-throughput

0.606

High

1169115

ZN574
Zinc finger protein 574

2

6

High-throughput

0.606

High

1237654

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

1

High-throughput

0.606

High

1251796

ZN417
Zinc finger protein 417

2

6

High-throughput

0.606

High

1302383

ZN587
Zinc finger protein 587

2

5

High-throughput

0.606

High

1313592

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

2

1

High-throughput

0.606

High

1314687

SCNM1
Sodium channel modifier 1

2

1

High-throughput

0.606

High

1344069

PAR11
Protein mono-ADP-ribosyltransferase PARP11

2

1

High-throughput

0.606

High

1348421

ABI2
Abl interactor 2

2

18

High-throughput

0.606

High

1350404

RCOR3
REST corepressor 3

2

8

High-throughput

0.606

High

1354096

CPNE7
Copine-7

2

1

High-throughput

0.606

High

212537

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

0

High-throughput

0.580

High

271002

GCM2
Chorion-specific transcription factor GCMb

2

0

High-throughput

0.580

High

968236

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

0

High-throughput

0.580

High

1293895

INT4
Integrator complex subunit 4

2

0

High-throughput

0.580

High

1333241

NRDE2
Nuclear exosome regulator NRDE2

2

0

High-throughput

0.580

High

1346798

FAIM1
Fas apoptotic inhibitory molecule 1

2

0

High-throughput

0.580

High

1018276

NFIA
Nuclear factor 1 A-type

1

14

High-throughput

0.578

High

135170

NFIB
Nuclear factor 1 B-type

1

10

High-throughput

0.561

High

443262

NFIC
Nuclear factor 1 C-type

1

14

High-throughput

0.561

High

600250

TAF1
Transcription initiation factor TFIID subunit 1

1

15

Small-scale

0.561

High

763370

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

1

Small-scale

0.561

High

243160

SH21A
SH2 domain-containing protein 1A

2

7

High-throughput

0.553

High

271209

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

1

High-throughput

0.553

High

330144

DRC4
Dynein regulatory complex subunit 4

2

1

High-throughput

0.553

High

517790

K2C3
Keratin, type II cytoskeletal 3

2

5

High-throughput

0.553

High

1046982

BYST
Bystin

2

2

High-throughput

0.553

High

1081163

CCDC6
Coiled-coil domain-containing protein 6

2

7

High-throughput

0.553

High

1103274

C19L2
CWF19-like protein 2

2

2

High-throughput

0.553

High

1103549

KLH38
Kelch-like protein 38

2

2

High-throughput

0.553

High

1122054

CTSRT
Cation channel sperm-associated targeting subunit tau

2

1

High-throughput

0.553

High

1191934

SEN54
tRNA-splicing endonuclease subunit Sen54

2

1

High-throughput

0.553

High

1223056

CC146
Coiled-coil domain-containing protein 146

2

3

High-throughput

0.553

High

1246234

GA2L2
GAS2-like protein 2

2

1

High-throughput

0.553

High

1299838

PNMA5
Paraneoplastic antigen-like protein 5

2

3

High-throughput

0.553

High

1310392

NUD22
Uridine diphosphate glucose pyrophosphatase NUDT22

2

1

High-throughput

0.553

High

1335459

PARVG
Gamma-parvin

2

4

High-throughput

0.553

High

63698

TSPY2
Testis-specific Y-encoded protein 2

1

1

High-throughput

0.536

High

793664

DCC
Netrin receptor DCC

1

4

High-throughput

0.536

High

946671

SSBP2
Single-stranded DNA-binding protein 2

1

20

High-throughput

0.536

High

1129662

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

1

High-throughput

0.536

High

1333162

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

1

High-throughput

0.536

High

1354243

IF172
Intraflagellar transport protein 172 homolog

1

1

Small-scale

0.523

High

1346936

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

Small-scale

0.501

High

164025

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.489

High

1205172

Z354C
Zinc finger protein 354C

1

7

High-throughput

0.481

High

1307479

CITE2
Cbp/p300-interacting transactivator 2

1

1

Small-scale

0.481

High

131749

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

146293

ARI1A
AT-rich interactive domain-containing protein 1A

1

18

High-throughput

0.479

High

152696

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

164280

ZN609
Zinc finger protein 609

1

10

High-throughput

0.479

High

170500

TIF1A
Transcription intermediary factor 1-alpha

1

9

High-throughput

0.479

High

183171

KDM6A
Lysine-specific demethylase 6A

1

4

High-throughput

0.479

High

231261

ZEB2
Zinc finger E-box-binding homeobox 2

1

7

High-throughput

0.479

High

257529

CREST
Calcium-responsive transactivator

1

12

High-throughput

0.479

High

261603

NCOR1
Nuclear receptor corepressor 1

1

18

High-throughput

0.479

High

265724

E2F6
Transcription factor E2F6

1

3

High-throughput

0.479

High

473572

ATX1L
Ataxin-1-like

1

5

High-throughput

0.479

High

525335

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

13

High-throughput

0.479

High

550441

ZEP1
Zinc finger protein 40

1

19

High-throughput

0.479

High

727819

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

824492

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

14

High-throughput

0.479

High

846888

SMCA2
Probable global transcription activator SNF2L2

1

12

High-throughput

0.479

High

867900

HIRA
Protein HIRA

1

1

High-throughput

0.479

High

868356

ATX3
Ataxin-3

1

1

Small-scale

0.479

High

868785

ATX1
Ataxin-1

1

5

High-throughput

0.479

High

952890

FOXK1
Forkhead box protein K1

1

7

High-throughput

0.479

High

980662

TLE1
Transducin-like enhancer protein 1

1

12

High-throughput

0.479

High

987807

GABPA
GA-binding protein alpha chain

1

6

High-throughput

0.479

High

988031

RING1
E3 ubiquitin-protein ligase RING1

1

7

High-throughput

0.479

High

1070800

RBBP5
Retinoblastoma-binding protein 5

1

1

High-throughput

0.479

High

1147488

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

1154080

NIPBL
Nipped-B-like protein

1

12

High-throughput

0.479

High

1159813

NFRKB
Nuclear factor related to kappa-B-binding protein

1

8

High-throughput

0.479

High

1162172

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

2

High-throughput

0.479

High

1173263

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

1189313

POGZ
Pogo transposable element with ZNF domain

1

8

High-throughput

0.479

High

1199211

PB1
Protein polybromo-1

1

16

High-throughput

0.479

High

1217566

FOXP4
Forkhead box protein P4

1

12

High-throughput

0.479

High

1225009

TAF1L
Transcription initiation factor TFIID subunit 1-like

1

16

High-throughput

0.479

High

1243849

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

1244313

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

1245605

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

1259976

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

1270594

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

1270721

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1270815

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

1272994

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

16

High-throughput

0.479

High

1282170

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

5

High-throughput

0.479

High

1292503

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

10

High-throughput

0.479

High

1296260

Z512B
Zinc finger protein 512B

1

13

High-throughput

0.479

High

1297803

ZN512
Zinc finger protein 512

1

9

High-throughput

0.479

High

1300973

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1306898

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1309600

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

8

High-throughput

0.479

High

1316713

PCGF6
Polycomb group RING finger protein 6

1

8

High-throughput

0.479

High

1317915

GTPB4
GTP-binding protein 4

1

3

High-throughput

0.479

High

1329971

FOXP1
Forkhead box protein P1

1

12

High-throughput

0.479

High

1331892

ZN644
Zinc finger protein 644

1

8

High-throughput

0.479

High

1332093

IKZF5
Zinc finger protein Pegasus

1

20

High-throughput

0.479

High

1342812

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

1345497

SALL1
Sal-like protein 1

1

7

High-throughput

0.479

High

1348270

DDX56
Probable ATP-dependent RNA helicase DDX56

1

5

High-throughput

0.479

High

1350240

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

7

High-throughput

0.479

High

1354244

TCF20
Transcription factor 20

1

12

High-throughput

0.479

High

1354251

INO80
Chromatin-remodeling ATPase INO80

1

13

High-throughput

0.479

High

1354252

PRR12
Proline-rich protein 12

1

12

High-throughput

0.479

High

1354254

SMC3
Structural maintenance of chromosomes protein 3

1

4

High-throughput

0.479

High

1354255

NCOR2
Nuclear receptor corepressor 2

1

19

High-throughput

0.479

High

486976

MYBB
Myb-related protein B

1

0

High-throughput

0.458

High

1255860

MORC4
MORC family CW-type zinc finger protein 4

1

0

High-throughput

0.458

High

1260556

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

787796

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.457

High

1292674

DDX27
Probable ATP-dependent RNA helicase DDX27

1

2

High-throughput

0.437

High

1310054

CG050
Uncharacterized protein C7orf50

1

3

High-throughput

0.437

High

1310381

PYGO2
Pygopus homolog 2

1

11

High-throughput

0.437

High

1122525

ACTBL
Beta-actin-like protein 2

1

7

High-throughput

0.407

High

59524

F221A
Protein FAM221A

2

0

High-throughput

0.316

High

260104

VATG1
V-type proton ATPase subunit G 1

2

0

High-throughput

0.316

High

600068

SAT1
Diamine acetyltransferase 1

2

0

High-throughput

0.316

High

850452

CLCKA
Chloride channel protein ClC-Ka

2

0

High-throughput

0.316

High

895457

CKS1
Cyclin-dependent kinases regulatory subunit 1

2

0

High-throughput

0.316

High

993302

ACTN3
Alpha-actinin-3

2

0

High-throughput

0.316

High

1093089

INSC
Protein inscuteable homolog

2

0

High-throughput

0.316

High

1238839

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

0

High-throughput

0.316

High

1286626

RHDF1
Inactive rhomboid protein 1

2

0

High-throughput

0.316

High

1298888

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1299522

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.316

High

1309709

AIF1L
Allograft inflammatory factor 1-like

2

0

High-throughput

0.316

High

1327842

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1332162

F124B
Protein FAM124B

2

0

High-throughput

0.316

High

1354246

PS1C2
Psoriasis susceptibility 1 candidate gene 2 protein

2

0

High-throughput

0.316

High

1354249

CDC23
Cell division cycle protein 23 homolog

2

0

High-throughput

0.316

High

234729

PLXC1
Plexin-C1

1

0

High-throughput

0.279

Low

1057865

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.279

Low

1354248

TSKS
Testis-specific serine kinase substrate

1

0

High-throughput

0.279

Low

1330065

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024