HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: IRS2 (Q9Y4H2)
Insulin receptor substrate 2 (IRS-2)
Gene: IRS2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.657

Property	Details
Experiments	36931259, 17979178, 9312143
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0019903 - protein phosphatase binding GO:0019904 - protein domain specific binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 1338
+	Hs
		724526 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Mm
		724581 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Hs
		151760 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Dm
		955052 1433E_DROME (1-254): 2.95e-146: 411: 82.69		IRS1_DROME (27-983): 1.28e-75: 274: 17.98
+	Hs
		297821 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		K0754_HUMAN (846-1326): 4.64e-29: 129: 11.90
+	Hs
		909737 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		TICRR_HUMAN (453-1197): 1.42e-14: 81.4: 13.74
+	Hs
		909712 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		OTOG_HUMAN (965-1323): 2.73e-11: 70.7: 11.75
+	Hs
		910111 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DAPLE_HUMAN (303-786): 4.42e-09: 63.4: 12.02