HitPredict

Interactor 1: POLO (P52304)
Serine/threonine-protein kinase polo (EC 2.7.11.21)
Gene: POLO

Interactor 2: Q95RV8 (Q95RV8)
LD09043p
Gene: Acf

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15710747
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 576 Dm			1 400
+	Dm
		911760 POLO_DROME (1-576): 0: 599: 100.00		Q9V9T4_DROME (1-400): 3.58e-80: 270: 100.00
+	Hs
		919914 PLK1_HUMAN (31-572): 0: 596: 52.67		EP300_HUMAN (36-388): 1.21e-39: 153: 13.67
+	Ce
		758680 PLK1_CAEEL (3-572): 0: 562: 44.33		CBP1_CAEEL (19-387): 9.1e-41: 156: 13.96
+	Ce
		758958 PLK1_CAEEL (3-572): 0: 562: 44.33		NU301_CAEEL (58-391): 4.02e-40: 154: 17.28
+	Dm
		900578 POLO_DROME (1-576): 0: 599: 100.00		TAF1_DROME (282-387): 6.9e-26: 112: 28.30
+	Hs
		920341 PLK1_HUMAN (31-572): 0: 596: 52.67		BAZ2A_HUMAN (1-107): 1.73e-13: 74.5: 18.69
+	Ce
		758885 PLK1_CAEEL (3-572): 0: 562: 44.33		Q20947_CAEEL (289-393): 9.87e-11: 65.9: 33.65
+	Sc
		448788 SNF1_YEAST (14-349): 5.44e-125: 383: 28.19		GCN5_YEAST (270-392): 3.71e-41: 152: 34.15
+	Hs
		658598 KS6B1_HUMAN (25-269): 9.31e-42: 159: 37.05		EP300_HUMAN (36-388): 1.21e-39: 153: 13.67
+	Hs
		658618 KS6B1_HUMAN (25-269): 9.31e-42: 159: 37.05		KAT2B_HUMAN (210-386): 3.24e-38: 148: 21.55
+	Hs
		674379 AURKC_HUMAN (29-294): 3.88e-42: 155: 31.96		BRD2_HUMAN (231-390): 1.94e-35: 140: 24.10
+	Hs
		169845 AURKA_HUMAN (29-290): 9.73e-45: 165: 31.30		BRD4_HUMAN (207-391): 2.84e-31: 128: 22.51