Protein: KS6B1
Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)

Gene: KS6B1, RPS6KB1
Organism: Homo sapiens
Interactions: 93
UniProt ID: P23443

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0001662 - behavioral fear response
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658583

EIF3B
Eukaryotic translation initiation factor 3 subunit B

4

4

Small-scale

0.896

High

658576

MK08
Mitogen-activated protein kinase 8

2

20

Small-scale

0.826

High

658622

PDIP3
Polymerase delta-interacting protein 3

2

4

Small-scale

0.815

High

543055

UBL4A
Ubiquitin-like protein 4A

2

14

High-throughput

0.811

High

658569

AKT1
RAC-alpha serine/threonine-protein kinase

3

16

Small-scale

0.799

High

658571

IRS1
Insulin receptor substrate 1

2

12

Small-scale

0.799

High

658573

MTOR
Serine/threonine-protein kinase mTOR

24

20

Small-scale

0.767

High

658565

KS6B1
Ribosomal protein S6 kinase beta-1

2

15

Small-scale

0.755

High

658612

RPTOR
Regulatory-associated protein of mTOR

12

15

Small-scale

0.754

High

193499

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

19

Small-scale

0.743

High

484054

PGFRB
Platelet-derived growth factor receptor beta

1

16

Small-scale

0.724

High

658588

CSK2B
Casein kinase II subunit beta

1

8

Small-scale

0.724

High

658624

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.724

High

466628

GLI1
Zinc finger protein GLI1

1

5

Small-scale

0.715

High

658585

RS6
Small ribosomal subunit protein eS6

4

10

Small-scale

0.688

High

658594

KPCZ
Protein kinase C zeta type

1

17

Small-scale

0.665

High

529095

TAU
Microtubule-associated protein tau

2

16

Small-scale

0.657

High

463334

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.647

High

507535

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

High-throughput

0.647

High

557097

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

658574

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.647

High

658589

ACTS
Actin, alpha skeletal muscle

1

15

Small-scale

0.647

High

658590

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.647

High

658595

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.647

High

658604

RHEB
GTP-binding protein Rheb

1

2

Small-scale

0.647

High

658603

PDK1
[Pyruvate dehydrogenase

3

6

Small-scale

0.641

High

131327

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

4

Small-scale

0.624

High

461158

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468082

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

658602

SQSTM
Sequestosome-1

1

4

Small-scale

0.618

High

658609

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

658616

TRIB2
Tribbles homolog 2

1

15

Small-scale

0.618

High

658627

IRS2
Insulin receptor substrate 2

1

10

Small-scale

0.618

High

421518

A4
Amyloid-beta precursor protein

2

12

High-throughput

0.611

High

658621

TRAF4
TNF receptor-associated factor 4

2

8

Small-scale

0.608

High

658608

RICTR
Rapamycin-insensitive companion of mTOR

2

7

Small-scale

0.595

High

658584

CDC42
Cell division control protein 42 homolog

1

11

Small-scale

0.590

High

658599

COASY
Bifunctional coenzyme A synthase

1

2

Small-scale

0.589

High

658587

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

5

Small-scale

0.584

High

247229

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

16

Small-scale

0.575

High

658600

PAK1
Serine/threonine-protein kinase PAK 1

1

17

Small-scale

0.575

High

658610

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

1

15

Small-scale

0.575

High

658580

MXI1
Max-interacting protein 1

1

6

Small-scale

0.561

High

658581

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

Small-scale

0.561

High

658598

EP300
Histone acetyltransferase p300

1

14

Small-scale

0.561

High

658618

KAT2B
Histone acetyltransferase KAT2B

1

5

Small-scale

0.561

High

658586

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.537

High

658593

MAD1
Max dimerization protein 1

1

6

Small-scale

0.536

High

445494

IF4E
Eukaryotic translation initiation factor 4E

1

1

Small-scale

0.536

High

658582

PPP5
Serine/threonine-protein phosphatase 5

1

14

High-throughput

0.536

High

407983

TBB4A
Tubulin beta-4A chain

1

17

High-throughput

0.515

High

658605

PDCD4
Programmed cell death protein 4

1

3

Small-scale

0.515

High

658625

GUAD
Guanine deaminase

1

1

High-throughput

0.515

High

559668

UNG
Uracil-DNA glycosylase

1

1

High-throughput

0.515

High

658568

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

High-throughput

0.515

High

658596

APLP2
Amyloid beta precursor like protein 2

1

11

High-throughput

0.515

High

658597

NCBP1
Nuclear cap-binding protein subunit 1

1

0

Small-scale

0.513

High

430715

TETN
Tetranectin

1

2

High-throughput

0.508

High

134437

EF2K
Eukaryotic elongation factor 2 kinase

1

2

Small-scale

0.501

High

282922

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

18

Small-scale

0.501

High

316351

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

Small-scale

0.501

High

658572

GRIA1
Glutamate receptor 1

1

9

Small-scale

0.501

High

658577

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

High-throughput

0.501

High

658578

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

4

Small-scale

0.501

High

658613

DPTOR
DEP domain-containing mTOR-interacting protein

1

5

Small-scale

0.501

High

658626

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

658591

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

Small-scale

0.500

High

658575

KI3L1
Killer cell immunoglobulin-like receptor 3DL1

1

10

High-throughput

0.494

High

658611

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.486

High

162906

TERT
Telomerase reverse transcriptase

1

2

Small-scale

0.479

High

172480

XPO1
Exportin-1

1

8

Small-scale

0.479

High

187888

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

6

Small-scale

0.479

High

340827

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

11

Small-scale

0.479

High

587934

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

591413

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

1

2

High-throughput

0.479

High

658566

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

658570

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

658592

MDM2
E3 ubiquitin-protein ligase Mdm2

1

6

Small-scale

0.479

High

658601

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.479

High

658607

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

658614

BICD2
Protein bicaudal D homolog 2

1

14

High-throughput

0.479

High

658615

RIN2
Ras and Rab interactor 2

1

12

High-throughput

0.479

High

658617

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

658619

BICD1
Protein bicaudal D homolog 1

1

15

High-throughput

0.479

High

658620

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

6

Small-scale

0.479

High

658623

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

658628

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

1

High-throughput

0.479

High

658567

CALX
Calnexin

1

1

High-throughput

0.470

High

658606

IER5
Immediate early response gene 5 protein

1

0

Small-scale

0.458

High

168817

PLD2
Phospholipase D2

1

3

Small-scale

0.437

High

352971

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

658579

SERPH
Serpin H1

1

6

High-throughput

0.437

High


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Last updated: 11Aug2025