HitPredict

Interactor 1: BTG1 (P62324)
Protein BTG1 (B-cell translocation gene 1 protein)
Gene: BTG1

Interactor 2: CNOT7 (Q9UIV1)
CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a)
Gene: CNOT7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

Property	Details
Experiments	29395067, 30217970, 9820826, 11136725, 21900206, 27107012
Identification Methods	proximity labelling technology, two hybrid, pull down, split luciferase complementation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BTG~CAF1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 171 Hs			1 285
+	Hs
		1152299 Q6IBC8_HUMAN (1-171): 7.14e-94: 271: 100.00		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Mm
		912801 BTG1_MOUSE (1-171): 7.14e-94: 271: 100.00		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Hs
		1152298 Q6IBC8_HUMAN (1-171): 7.14e-94: 271: 100.00		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Hs
		912793 BTG1_HUMAN (1-171): 7.14e-94: 271: 100.00		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Mm
		912802 BTG1_MOUSE (1-171): 7.14e-94: 271: 100.00		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24
+	Hs
		944599 BTG2_HUMAN (5-170): 5.3e-80: 235: 62.05		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Mm
		978994 BTG2_MOUSE (5-170): 5.13e-80: 235: 60.84		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Hs
		944598 BTG2_HUMAN (5-170): 5.3e-80: 235: 62.05		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Mm
		978995 BTG2_MOUSE (5-170): 5.13e-80: 235: 60.84		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24
+	Hs
		841404 TOB1_HUMAN (11-142): 7.57e-59: 188: 40.15		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Hs
		1048317 TOB2_HUMAN (11-141): 5.74e-55: 178: 40.15		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Mm
		251045 BTG4_MOUSE (11-152): 1.72e-55: 176: 34.21		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Hs
		841403 TOB1_HUMAN (11-142): 7.57e-59: 188: 40.15		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Hs
		1048316 TOB2_HUMAN (11-141): 5.74e-55: 178: 40.15		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Mm
		251046 BTG4_MOUSE (11-152): 1.72e-55: 176: 34.21		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24
+	Hs
		1051207 BTG3_HUMAN (11-118): 3.88e-44: 147: 42.73		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Hs
		1051204 BTG3_HUMAN (11-118): 3.88e-44: 147: 42.73		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Dm
		1155377 Q6NQY2_DROME (11-127): 3.59e-51: 172: 37.61		Q9VTS4_DROME (2-273): 2.28e-156: 439: 72.26
+	Dm
		60235 A4V4L0_DROME (11-127): 2.03e-48: 165: 38.46		X2JCC3_DROME (2-256): 5.58e-145: 412: 68.87