Protein: TBC25
TBC1 domain family member 25

Gene: TBC25, TBC1D25
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q3MII6

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005776 - autophagosome
GO:0006914 - autophagy
GO:0031410 - cytoplasmic vesicle
GO:1901096 - regulation of autophagosome maturation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

956317

RAB2A
Ras-related protein Rab-2A

3

20

Small-scale

0.755

High

952196

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

6

20

Small-scale

0.736

High

1187137

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

5

20

Small-scale

0.724

High

328037

GBRAP
Gamma-aminobutyric acid receptor-associated protein

4

20

Small-scale

0.701

High

1187149

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

4

High-throughput

0.618

High

1187135

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

20

High-throughput

0.606

High

1187134

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1187138

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

Small-scale

0.561

High

1187115

LAR1B
La-related protein 1B

2

1

High-throughput

0.553

High

1187121

FAM9B
Protein FAM9B

2

1

High-throughput

0.553

High

1187122

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

1

High-throughput

0.553

High

1187124

PPL13
Placental protein 13-like

2

2

High-throughput

0.553

High

719227

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.553

High

1049351

1433F
14-3-3 protein eta

2

20

High-throughput

0.549

High

1187136

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

Small-scale

0.527

High

269558

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.479

High

1187117

SYDE1
Rho GTPase-activating protein SYDE1

1

2

High-throughput

0.479

High

687246

HMGB2
High mobility group protein B2

1

2

Small-scale

0.464

High

208673

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

1187131

FEZ1
Fasciculation and elongation protein zeta-1

1

1

Small-scale

0.439

High

1187145

FEZ2
Fasciculation and elongation protein zeta-2

1

1

Small-scale

0.439

High

176831

DCLK1
Serine/threonine-protein kinase DCLK1

1

1

High-throughput

0.437

High

281332

GGYF1
GRB10-interacting GYF protein 1

1

3

High-throughput

0.437

High

404099

GCR
Glucocorticoid receptor

1

6

High-throughput

0.437

High

936342

AFAD
Afadin

1

15

High-throughput

0.437

High

1025551

CDK16
Cyclin-dependent kinase 16

1

3

High-throughput

0.437

High

1187114

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.437

High

1187116

AN34A
Ankyrin repeat domain-containing protein 34A

1

2

High-throughput

0.437

High

1187119

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.437

High

1187123

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1187125

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.437

High

1187126

SRS12
Serine/arginine-rich splicing factor 12

1

4

High-throughput

0.437

High

1187128

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.437

High

1187129

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

5

High-throughput

0.437

High

1187130

TESK2
Dual specificity testis-specific protein kinase 2

1

4

High-throughput

0.437

High

1187133

F110A
Protein FAM110A

1

1

High-throughput

0.437

High

1187139

KI13B
Kinesin-like protein KIF13B

1

5

High-throughput

0.437

High

1187144

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.437

High

1187147

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.437

High

1187150

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.437

High

1187152

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.437

High

388209

GLPA
Glycophorin-A

1

1

High-throughput

0.407

High

729886

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.407

High

1187118

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

617227

ATF4
Cyclic AMP-dependent transcription factor ATF-4

2

0

High-throughput

0.319

High

1187120

LMTD2
Lamin tail domain-containing protein 2

2

0

High-throughput

0.316

High

1187141

KCIP1
A-type potassium channel modulatory protein KCNIP1

2

0

High-throughput

0.316

High

425808

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

High-throughput

0.279

Low

1187127

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.279

Low

1187151

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.269

Low

252072

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.249

Low

1133975

ZN638
Zinc finger protein 638

1

0

High-throughput

0.249

Low

1187132

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.249

Low

1187140

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1187142

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.249

Low

1187143

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

1187146

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.249

Low

1187148

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025