HitPredict

Interactor 1: TIA1 (P52912)
Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1)
Gene: TIA1

Interactor 2: SRSF2 (Q62093)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Putative myelin regulatory factor 1) (MRF-1) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27160897
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0006397 - mRNA processing GO:0008380 - RNA splicing
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 386 Mm			1 221
+	Hs
		726735 TIA1_HUMAN (1-386): 4.08e-112: 334: 96.63		TIA1_HUMAN (9-182): 8.58e-16: 76.9: 10.73
+	Hs
		726752 TIA1_HUMAN (1-386): 4.08e-112: 334: 96.63		TIAR_HUMAN (9-142): 1.28e-15: 76.6: 9.70
+	Mm
		710979 TIA1_MOUSE (1-386): 9.38e-114: 338: 100.00		PABP1_MOUSE (104-194): 1.09e-10: 62.3: 9.89
+	Hs
		550137 TIA1_HUMAN (1-386): 4.08e-112: 334: 96.63		PABP1_HUMAN (104-194): 9.81e-11: 62.7: 9.89
+	Hs
		550250 PABP1_HUMAN (3-303): 1.46e-66: 224: 24.68		ELAV2_HUMAN (1-195): 3.76e-37: 134: 15.79
+	Dm
		1303439 Q8IMX4_DROME (1-381): 6.16e-76: 244: 36.02		Q9VAX3_DROME (14-102): 1.14e-27: 111: 30.34
+	Hs
		550262 PABP1_HUMAN (3-303): 1.46e-66: 224: 24.68		PABP4_HUMAN (5-191): 3.38e-24: 101: 13.37
+	Hs
		550508 PABP1_HUMAN (3-303): 1.46e-66: 224: 24.68		PUF60_HUMAN (8-108): 8.36e-24: 100: 23.76
+	Hs
		550407 PABP1_HUMAN (3-303): 1.46e-66: 224: 24.68		PABP5_HUMAN (16-95): 2.24e-18: 84.4: 21.25
+	Hs
		550237 PABP1_HUMAN (3-303): 1.46e-66: 224: 24.68		TIAR_HUMAN (9-142): 1.28e-15: 76.6: 9.70
+	Hs
		550311 PABP1_HUMAN (3-303): 1.46e-66: 224: 24.68		PAP1L_HUMAN (104-193): 5.91e-11: 63.1: 8.89
+	Hs
		550097 PABP1_HUMAN (3-303): 1.46e-66: 224: 24.68		PABP1_HUMAN (104-194): 9.81e-11: 62.7: 9.89
+	Hs
		550464 PABP1_HUMAN (3-303): 1.46e-66: 224: 24.68		PABP3_HUMAN (104-194): 8.31e-09: 56.9: 9.89
+	Hs
		506127 PAB4L_HUMAN (103-303): 1.03e-39: 146: 23.42		ELAV2_HUMAN (1-195): 3.76e-37: 134: 15.79
+	Hs
		1197174 PAP1L_HUMAN (7-199): 1.49e-47: 172: 25.89		PABP5_HUMAN (16-95): 2.24e-18: 84.4: 21.25
+	Hs
		506129 PAB4L_HUMAN (103-303): 1.03e-39: 146: 23.42		PABP4_HUMAN (5-191): 3.38e-24: 101: 13.37
+	Hs
		1197178 PAP1L_HUMAN (7-199): 1.49e-47: 172: 25.89		PABP3_HUMAN (104-194): 8.31e-09: 56.9: 9.89