HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 196 Hs			1 1746
+	Hs
		925619 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		900910 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		545621 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		436511 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		951343 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		892599 RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		894437 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		564687 RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		120644 RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		681775 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568619 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568611 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		436148 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568605 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		900861 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		PINK1_HUMAN (1357-1669): 2.87e-73: 258: 23.64
+	Hs
		616691 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17
+	Ce
		136793 RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		104464 G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		136800 RHO1_CAEEL (1-196): 4.36e-75: 225: 78.57		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80