Protein: CDC20
Cell division cycle protein 20 homolog (p55CDC)

Gene: CDC20
Organism: Homo sapiens
Interactions: 222
UniProt ID: Q12834

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1017373

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

74

9

Small-scale

0.998

High

236918

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

67

20

Small-scale

0.998

High

1017461

APC4
Anaphase-promoting complex subunit 4

25

7

Small-scale

0.989

High

211164

BUB3
Mitotic checkpoint protein BUB3

14

19

Small-scale

0.979

High

211008

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

11

17

Small-scale

0.978

High

1017459

APC7
Anaphase-promoting complex subunit 7

12

20

Small-scale

0.971

High

1017370

CDC20
Cell division cycle protein 20 homolog

7

19

Small-scale

0.957

High

1017464

FZR1
Fizzy-related protein homolog

5

19

Small-scale

0.922

High

1017389

UBE2S
Ubiquitin-conjugating enzyme E2 S

4

8

Small-scale

0.896

High

135932

UBE2C
Ubiquitin-conjugating enzyme E2 C

4

7

Small-scale

0.888

High

1017457

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

3

9

Small-scale

0.871

High

672820

CDC27
Cell division cycle protein 27 homolog

61

20

Small-scale

0.772

High

538532

CCNB1
G2/mitotic-specific cyclin-B1

34

20

Small-scale

0.770

High

330196

PTTG1
Securin

28

1

Small-scale

0.769

High

590171

CCNA2
Cyclin-A2

19

20

Small-scale

0.767

High

1017371

CDC16
Cell division cycle protein 16 homolog

13

20

Small-scale

0.759

High

1017462

ANC2
Anaphase-promoting complex subunit 2

12

20

Small-scale

0.756

High

1017458

CDC23
Cell division cycle protein 23 homolog

10

20

Small-scale

0.751

High

1017420

APC16
Anaphase-promoting complex subunit 16

7

1

Small-scale

0.745

High

1017434

APC1
Anaphase-promoting complex subunit 1

9

10

Small-scale

0.744

High

625397

CDK2
Cyclin-dependent kinase 2

6

17

Small-scale

0.733

High

1017374

SKP2
S-phase kinase-associated protein 2

6

4

Small-scale

0.730

High

1017460

APC5
Anaphase-promoting complex subunit 5

6

5

Small-scale

0.724

High

1017383

MD2BP
MAD2L1-binding protein

10

0

Small-scale

0.722

High

758209

CDN1A
Cyclin-dependent kinase inhibitor 1

5

2

Small-scale

0.714

High

826632

TCPG
T-complex protein 1 subunit gamma

5

20

Small-scale

0.714

High

1017427

TCPH
T-complex protein 1 subunit eta

5

20

Small-scale

0.714

High

821182

TCPE
T-complex protein 1 subunit epsilon

5

20

Small-scale

0.711

High

1017411

CDC26
Anaphase-promoting complex subunit CDC26

5

1

Small-scale

0.706

High

1017465

APC10
Anaphase-promoting complex subunit 10

5

10

Small-scale

0.699

High

414894

CDK1
Cyclin-dependent kinase 1

4

16

Small-scale

0.694

High

861722

PLK1
Serine/threonine-protein kinase PLK1

4

11

Small-scale

0.694

High

943205

TCPB
T-complex protein 1 subunit beta

4

20

Small-scale

0.686

High

851317

NEK2
Serine/threonine-protein kinase Nek2

4

8

Small-scale

0.683

High

1017448

APC11
Anaphase-promoting complex subunit 11

4

4

Small-scale

0.683

High

1017446

RASF1
Ras association domain-containing protein 1

3

5

Small-scale

0.670

High

887544

APC15
Anaphase-promoting complex subunit 15

3

1

Small-scale

0.667

High

895422

CKS1
Cyclin-dependent kinases regulatory subunit 1

3

6

Small-scale

0.667

High

998616

EP300
Histone acetyltransferase p300

3

18

Small-scale

0.667

High

1017471

AXIN2
Axin-2

1

2

Small-scale

0.665

High

943780

CCNA1
Cyclin-A1

3

20

Small-scale

0.665

High

1017463

FBX5
F-box only protein 5

3

6

Small-scale

0.664

High

475676

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

9

Small-scale

0.655

High

267148

GEMI
Geminin

3

2

Small-scale

0.646

High

1017472

SYYM
Tyrosine--tRNA ligase, mitochondrial

3

0

High-throughput

0.643

High

227298

PRKN
E3 ubiquitin-protein ligase parkin

3

18

Small-scale

0.640

High

573235

TCPA
T-complex protein 1 subunit alpha

3

20

Small-scale

0.640

High

770805

TCPZ
T-complex protein 1 subunit zeta

3

20

Small-scale

0.640

High

842843

TCPQ
T-complex protein 1 subunit theta

3

20

Small-scale

0.640

High

843174

TCPD
T-complex protein 1 subunit delta

3

20

Small-scale

0.640

High

224931

ZNRD2
Protein ZNRD2

2

1

High-throughput

0.628

High

1017476

PCDC2
Protocadherin alpha-C2

2

2

High-throughput

0.628

High

214235

SPOP
Speckle-type POZ protein

2

3

Small-scale

0.624

High

930818

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

6

Small-scale

0.624

High

961076

HSF1
Heat shock factor protein 1

2

6

Small-scale

0.624

High

1017382

MDC1
Mediator of DNA damage checkpoint protein 1

2

20

Small-scale

0.624

High

1017441

EGLN3
Prolyl hydroxylase EGLN3

2

2

Small-scale

0.624

High

857968

NUP98
Nuclear pore complex protein Nup98-Nup96

1

7

Small-scale

0.618

High

903176

WDR5
WD repeat-containing protein 5

1

18

Small-scale

0.618

High

1017403

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

5

Small-scale

0.618

High

1017433

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

11

High-throughput

0.618

High

1017445

ANLN
Anillin

1

4

High-throughput

0.618

High

1017468

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

8

Small-scale

0.618

High

1017469

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.618

High

1017473

TRRAP
Transformation/transcription domain-associated protein

1

9

Small-scale

0.618

High

160536

AURKA
Aurora kinase A

2

10

Small-scale

0.611

High

1017467

PHF8
Histone lysine demethylase PHF8

2

8

Small-scale

0.611

High

394620

A4
Amyloid-beta precursor protein

2

4

High-throughput

0.602

High

1017419

DCPS
m7GpppX diphosphatase

2

1

Small-scale

0.602

High

527983

RINI
Ribonuclease inhibitor

2

0

High-throughput

0.602

High

1017418

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.586

High

304142

UBR5
E3 ubiquitin-protein ligase UBR5

2

12

Small-scale

0.584

High

322535

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

16

Small-scale

0.584

High

346645

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

840206

MXI1
Max-interacting protein 1

2

15

Small-scale

0.584

High

963601

E2F1
Transcription factor E2F1

2

4

Small-scale

0.584

High

1017385

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

2

2

Small-scale

0.584

High

1017391

FBX43
F-box only protein 43

2

6

Small-scale

0.584

High

1017415

CBP
CREB-binding protein

2

15

Small-scale

0.584

High

1017477

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

16

Small-scale

0.584

High

978732

TF65
Transcription factor p65

1

4

Small-scale

0.578

High

1017437

P63
Tumor protein 63

1

7

Small-scale

0.578

High

1017401

SPERI
Speriolin

1

7

Small-scale

0.573

High

1017407

SH2D3
SH2 domain-containing protein 3C

2

5

High-throughput

0.571

High

507563

PIM1
Serine/threonine-protein kinase pim-1

1

8

Small-scale

0.561

High

977882

HSF2
Heat shock factor protein 2

1

6

Small-scale

0.561

High

992158

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

3

Small-scale

0.561

High

1017395

OTU7B
OTU domain-containing protein 7B

1

5

Small-scale

0.561

High

1017405

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

7

Small-scale

0.561

High

1017456

TBK1
Serine/threonine-protein kinase TBK1

1

8

Small-scale

0.561

High

1017397

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

1017413

PKHO2
Pleckstrin homology domain-containing family O member 2

1

6

High-throughput

0.553

High

1017430

EIF2A
Eukaryotic translation initiation factor 2A

1

20

High-throughput

0.553

High

1017440

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.553

High

175862

P73
Tumor protein p73

1

7

Small-scale

0.536

High

243380

DNJA2
DnaJ homolog subfamily A member 2

1

12

High-throughput

0.536

High

706800

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

6

High-throughput

0.536

High

970693

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

2

High-throughput

0.536

High

1017376

HDAC1
Histone deacetylase 1

1

14

Small-scale

0.536

High

1017402

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.536

High

1017414

HDAC2
Histone deacetylase 2

1

14

Small-scale

0.536

High

1017416

CSN5
COP9 signalosome complex subunit 5

1

10

High-throughput

0.536

High

1017425

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

1017447

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

7

High-throughput

0.536

High

280493

KT33A
Keratin, type I cuticular Ha3-I

1

17

High-throughput

0.515

High

943667

KRT85
Keratin, type II cuticular Hb5

1

9

High-throughput

0.515

High

989273

PRDX1
Peroxiredoxin-1

1

7

High-throughput

0.515

High

1017381

K1H2
Keratin, type I cuticular Ha2

1

17

High-throughput

0.515

High

1017386

K1H1
Keratin, type I cuticular Ha1

1

17

High-throughput

0.515

High

1017431

KRA93
Keratin-associated protein 9-3

1

1

High-throughput

0.515

High

1017432

KRA92
Keratin-associated protein 9-2

1

1

High-throughput

0.515

High

1017443

RDH14
Retinol dehydrogenase 14

1

0

High-throughput

0.513

High

1017475

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

378679

KITH
Thymidine kinase, cytosolic

1

1

Small-scale

0.501

High

707610

H2B1B
Histone H2B type 1-B

1

8

Small-scale

0.501

High

801107

KI67
Proliferation marker protein Ki-67

1

19

Small-scale

0.501

High

934703

H31
Histone H3.1

1

9

Small-scale

0.501

High

1017372

FADD
FAS-associated death domain protein

1

1

Small-scale

0.501

High

1017387

PCH2
Pachytene checkpoint protein 2 homolog

1

14

Small-scale

0.501

High

1017412

KI18A
Kinesin-like protein KIF18A

1

5

Small-scale

0.501

High

1017426

CDC6
Cell division control protein 6 homolog

1

4

Small-scale

0.501

High

1017436

CDT1
DNA replication factor Cdt1

1

1

Small-scale

0.501

High

1017390

KR195
Keratin-associated protein 19-5

1

0

High-throughput

0.493

High

1017450

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.493

High

116997

SGK1
Serine/threonine-protein kinase Sgk1

1

10

High-throughput

0.479

High

162681

XPO1
Exportin-1

1

13

High-throughput

0.479

High

208259

DCX
Neuronal migration protein doublecortin

1

1

Small-scale

0.479

High

318612

EYA4
Eyes absent homolog 4

1

15

High-throughput

0.479

High

374131

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

385866

CPNS1
Calpain small subunit 1

1

2

High-throughput

0.479

High

386626

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

428166

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

475010

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

9

High-throughput

0.479

High

486902

MYBB
Myb-related protein B

1

9

Small-scale

0.479

High

499716

CH60
60 kDa heat shock protein, mitochondrial

1

11

High-throughput

0.479

High

502031

BIP
Endoplasmic reticulum chaperone BiP

1

17

High-throughput

0.479

High

503983

HSP7C
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.479

High

507968

FGFR1
Fibroblast growth factor receptor 1

1

11

High-throughput

0.479

High

517226

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.479

High

552593

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

614020

TBG1
Tubulin gamma-1 chain

1

20

Small-scale

0.479

High

616277

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.479

High

651065

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

672096

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

10

Small-scale

0.479

High

673393

MPIP1
M-phase inducer phosphatase 1

1

2

High-throughput

0.479

High

673474

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.479

High

708286

TTK
Dual specificity protein kinase TTK

1

8

Small-scale

0.479

High

713951

HS71L
Heat shock 70 kDa protein 1-like

1

13

High-throughput

0.479

High

720332

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

723690

HXD13
Homeobox protein Hox-D13

1

3

Small-scale

0.479

High

779315

CCNF
Cyclin-F

1

20

Small-scale

0.479

High

780963

ID1
DNA-binding protein inhibitor ID-1

1

5

Small-scale

0.479

High

804116

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

2

Small-scale

0.479

High

808556

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

822460

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

Small-scale

0.479

High

830942

CTCF
Transcriptional repressor CTCF

1

3

Small-scale

0.479

High

841686

CDK9
Cyclin-dependent kinase 9

1

18

High-throughput

0.479

High

855033

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

20

High-throughput

0.479

High

867043

IST1
IST1 homolog

1

1

Small-scale

0.479

High

904500

1433G
14-3-3 protein gamma

1

19

High-throughput

0.479

High

910395

RS14
Small ribosomal subunit protein uS11

1

6

Small-scale

0.479

High

915172

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

6

Small-scale

0.479

High

919371

RL23
Large ribosomal subunit protein uL14

1

5

High-throughput

0.479

High

931117

YBOX1
Y-box-binding protein 1

1

7

Small-scale

0.479

High

933418

TBA4A
Tubulin alpha-4A chain

1

20

High-throughput

0.479

High

933774

TBB4B
Tubulin beta-4B chain

1

20

High-throughput

0.479

High

940834

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

962038

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

15

Small-scale

0.479

High

974248

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

4

Small-scale

0.479

High

981962

1433F
14-3-3 protein eta

1

19

High-throughput

0.479

High

1016157

FOXO1
Forkhead box protein O1

1

9

Small-scale

0.479

High

1017375

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.479

High

1017377

CUL1
Cullin-1

1

20

Small-scale

0.479

High

1017378

CUL3
Cullin-3

1

20

Small-scale

0.479

High

1017380

TFDP1
Transcription factor Dp-1

1

2

Small-scale

0.479

High

1017384

TNIP1
TNFAIP3-interacting protein 1

1

8

High-throughput

0.479

High

1017388

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

2

Small-scale

0.479

High

1017393

DAB2P
Disabled homolog 2-interacting protein

1

5

Small-scale

0.479

High

1017394

FBX31
F-box only protein 31

1

1

Small-scale

0.479

High

1017396

FBX42
F-box only protein 42

1

4

High-throughput

0.479

High

1017398

CE128
Centrosomal protein of 128 kDa

1

17

High-throughput

0.479

High

1017399

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

1017400

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.479

High

1017404

PB1
Protein polybromo-1

1

14

High-throughput

0.479

High

1017408

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

1017410

KNL1
Kinetochore scaffold 1

1

3

Small-scale

0.479

High

1017417

RNF34
E3 ubiquitin-protein ligase RNF34

1

7

Small-scale

0.479

High

1017421

CHFR
E3 ubiquitin-protein ligase CHFR

1

9

Small-scale

0.479

High

1017422

AURKB
Aurora kinase B

1

10

Small-scale

0.479

High

1017424

MAML3
Mastermind-like protein 3

1

11

High-throughput

0.479

High

1017428

TBA1C
Tubulin alpha-1C chain

1

20

High-throughput

0.479

High

1017439

CUED2
CUE domain-containing protein 2

1

1

Small-scale

0.479

High

1017442

CLSPN
Claspin

1

8

Small-scale

0.479

High

1017444

MOV10
Helicase MOV-10

1

8

High-throughput

0.479

High

1017451

HECW2
E3 ubiquitin-protein ligase HECW2

1

7

High-throughput

0.479

High

1017452

HDAC6
Histone deacetylase 6

1

18

Small-scale

0.479

High

1017453

DAXX
Death domain-associated protein 6

1

1

Small-scale

0.479

High

1017454

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1017455

KDM5B
Lysine-specific demethylase 5B

1

7

Small-scale

0.479

High

1017466

TRI33
E3 ubiquitin-protein ligase TRIM33

1

19

Small-scale

0.479

High

1017470

NINL
Ninein-like protein

1

14

Small-scale

0.479

High

307967

ZWINT
ZW10 interactor

1

0

Small-scale

0.458

High

1017392

FRY
Protein furry homolog

1

0

High-throughput

0.458

High

1017409

BANP
Protein BANP

1

0

Small-scale

0.458

High

967554

CDR2
Cerebellar degeneration-related protein 2

1

1

Small-scale

0.457

High

1017429

APC13
Anaphase-promoting complex subunit 13

1

1

High-throughput

0.445

High

49610

LNP1
Leukemia NUP98 fusion partner 1

1

1

Small-scale

0.437

High

199884

SPIT2
Kunitz-type protease inhibitor 2

1

4

High-throughput

0.437

High

259664

CILP1
Cartilage intermediate layer protein 1

1

1

High-throughput

0.437

High

351364

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

2

High-throughput

0.437

High

751598

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.437

High

993100

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

4

Small-scale

0.437

High

995957

DSC1
Desmocollin-1

1

3

High-throughput

0.437

High

1017379

TBB2A
Tubulin beta-2A chain

1

20

High-throughput

0.437

High

1017406

RAVR1
Ribonucleoprotein PTB-binding 1

1

15

High-throughput

0.437

High

1017423

DDRGK
DDRGK domain-containing protein 1

1

3

Small-scale

0.437

High

1017435

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

8

High-throughput

0.437

High

1017438

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.437

High

1017449

T2R13
Taste receptor type 2 member 13

1

1

Small-scale

0.437

High

118288

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

1017474

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024