HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: SSRP1 (Q08945)
FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)
Gene: SSRP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.944

Property	Details
Experiments	28514442, 30804502, 33961781, 37071682, 35271311, 21969370
Identification Methods	affinity chromatography technology, cross-linking study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CENP-T_C~Rtt106
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 709
+	Ce
		136663 H4_CAEEL (1-103): 1.41e-48: 151: 99.03		SSP1B_CAEEL (1-695): 0: 648: 36.25
+	Ce
		784738 H4_CAEEL (1-103): 1.41e-48: 151: 99.03		SSP1A_CAEEL (1-617): 0: 644: 39.94
+	Sc
		356709 H4_YEAST (18-103): 6.13e-41: 132: 90.70		POB3_YEAST (4-504): 0: 541: 29.66
+	Hs
		917971 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HM20A_HUMAN (460-709): 1.81e-42: 159: 17.20
+	Hs
		917780 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CIC_HUMAN (424-708): 7.87e-39: 157: 16.49
+	Hs
		918056 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HM20B_HUMAN (508-709): 6.25e-36: 139: 18.81
+	Hs
		297483 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		TOX4_HUMAN (484-678): 7.24e-32: 133: 23.86
+	Sc
		356507 H4_YEAST (18-103): 6.13e-41: 132: 90.70		RT106_YEAST (337-544): 3.23e-31: 129: 17.37
+	Sc
		356198 H4_YEAST (18-103): 6.13e-41: 132: 90.70		NHP6A_YEAST (530-619): 6.02e-28: 109: 35.56
+	Sc
		356199 H4_YEAST (18-103): 6.13e-41: 132: 90.70		NHP6B_YEAST (520-619): 7.39e-28: 109: 34.00
+	Hs
		643301 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HMGB2_HUMAN (540-698): 5.17e-15: 76.3: 23.53
+	Hs
		449647 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HMGB1_HUMAN (543-634): 1e-14: 75.5: 34.04
+	Hs
		567667 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		UBF1_HUMAN (416-655): 2.71e-11: 69: 14.52
+	Hs
		175766 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HMGB3_HUMAN (551-696): 3.34e-11: 65.2: 22.58