HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: H2AV (Q71UI9)
Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2)
Gene: H2AZ2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30804502, 37071682
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone, CENP-T_C~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 128
+	Hs
		469987 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2AZ_HUMAN (1-127): 3.62e-60: 182: 98.43
+	Dm
		446313 H4_DROME (1-103): 4.51e-48: 150: 99.03		H2AV_DROME (1-125): 1.92e-59: 181: 96.00
+	Hs
		917354 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2C_HUMAN (5-128): 2.15e-54: 168: 62.40
+	Hs
		917544 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2B_HUMAN (5-127): 1.29e-54: 168: 60.48
+	Hs
		917817 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1J_HUMAN (5-125): 1.65e-54: 168: 62.30
+	Hs
		917757 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1H_HUMAN (5-125): 4.19e-54: 167: 62.30
+	Hs
		391638 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1B_HUMAN (5-125): 1.25e-53: 166: 62.30
+	Hs
		470324 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1_HUMAN (5-125): 1.18e-53: 166: 62.30
+	Hs
		555395 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2AX_HUMAN (5-124): 1.36e-53: 166: 62.81
+	Hs
		594838 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1D_HUMAN (5-125): 9.61e-54: 166: 63.12
+	Hs
		917438 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A2A_HUMAN (5-125): 7.47e-54: 166: 63.12
+	Hs
		917496 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A3_HUMAN (5-125): 8.16e-54: 166: 63.12
+	Hs
		917699 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		H2A1C_HUMAN (5-125): 9.3e-54: 166: 62.30
+	Hs
		470137 H4G_HUMAN (1-98): 1.04e-38: 126: 84.69		H2AZ_HUMAN (1-127): 3.62e-60: 182: 98.43
+	Sc
		356810 H4_YEAST (18-103): 6.13e-41: 132: 90.70		H2AZ_YEAST (4-126): 3.22e-39: 129: 66.67