HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: TNPO1 (Q92973)
Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
Gene: TNPO1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.944

Property	Details
Experiments	10353245, 12384575, 35271311, 27114554, 11024021, 10944119
Identification Methods	x-ray crystallography, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	IBN_N~Ras
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 216 Hs			1 898
+	Dm
		1373317 RANL_DROME (1-210): 2.56e-93: 273: 60.48		Q9VRV8_DROME (11-898): 0: 617: 73.49
+	Hs
		155560 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		TNPO2_HUMAN (11-898): 0: 613: 84.30
+	At
		784988 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		TNPO1_ARATH (9-895): 3.03e-161: 496: 43.70
+	At
		784992 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		IMB1_ARATH (19-873): 2.06e-97: 326: 15.33
+	Sc
		698781 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		IMB2_YEAST (9-895): 1.68e-104: 346: 31.22
+	Sc
		699003 GSP2_YEAST (1-214): 1.18e-80: 241: 79.72		IMB2_YEAST (9-895): 1.68e-104: 346: 31.22
+	At
		784999 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		IMB1_ARATH (19-873): 2.06e-97: 326: 15.33
+	At
		1210454 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		IMB1_ARATH (19-873): 2.06e-97: 326: 15.33
+	Hs
		127238 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IPO5_HUMAN (21-879): 2.71e-91: 314: 16.85
+	Sc
		698945 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		IMB1_YEAST (22-840): 2.35e-87: 299: 16.04
+	Hs
		919077 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IMB1_HUMAN (21-862): 1.01e-87: 300: 16.15
+	Hs
		874484 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		XPO2_HUMAN (14-897): 9.98e-87: 299: 12.98
+	Hs
		312234 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IPO7_HUMAN (21-851): 6.08e-77: 273: 14.49
+	Sc
		687908 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		IMB3_YEAST (17-671): 3.09e-38: 156: 17.57
+	Sc
		687909 GSP2_YEAST (1-214): 1.18e-80: 241: 79.72		IMB3_YEAST (17-671): 3.09e-38: 156: 17.57
+	Hs
		919182 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IPO4_HUMAN (33-772): 2e-27: 122: 17.91
+	Hs
		236414 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		RNBP6_HUMAN (12-561): 1.14e-12: 74.2: 12.25