HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: ANC2 (Q9UJX6)
Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)
Gene: ANAPC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12956947
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ANAPC2~UQ_con
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 822
+	Dm
		639413 UBCD1_DROME (1-147): 2.75e-82: 239: 94.56		Q9W1E5_DROME (73-819): 0: 637: 37.15
+	Hs
		849326 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		CUL4A_HUMAN (244-806): 1.6e-151: 464: 16.42
+	Hs
		895791 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		CUL4A_HUMAN (244-806): 1.6e-151: 464: 16.42
+	Hs
		895792 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		CUL4B_HUMAN (244-812): 1.06e-144: 451: 16.06
+	Hs
		1043149 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		CUL4A_HUMAN (244-806): 1.6e-151: 464: 16.42
+	Hs
		849325 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Hs
		919724 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Hs
		828994 UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16		CUL4B_HUMAN (244-812): 1.06e-144: 451: 16.06
+	Hs
		1041136 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		CUL1_HUMAN (171-811): 5.04e-137: 426: 13.85
+	Hs
		1042304 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Hs
		1042223 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Hs
		851812 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Hs
		896438 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Hs
		849324 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		CUL2_HUMAN (270-802): 8.7e-120: 381: 12.77
+	Dm
		639393 UBCD1_DROME (1-147): 2.75e-82: 239: 94.56		CUL1_DROME (171-811): 7.67e-120: 381: 12.76
+	Hs
		895790 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		CUL2_HUMAN (270-802): 8.7e-120: 381: 12.77
+	At
		1228143 COP10_ARATH (4-146): 4.37e-58: 180: 56.64		CUL4_ARATH (72-808): 2.92e-140: 435: 14.16
+	Sp
		804458 UBC4_SCHPO (1-147): 1.21e-80: 236: 84.35		CUL3_SCHPO (439-808): 6.49e-82: 280: 18.03