HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: TENS2 (Q63HR2)
Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)
Gene: TNS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28675297
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1409
+	Hs
		782795 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		TENS2_HUMAN (1-1409): 0: 748: 100.00
+	Hs
		782797 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		523025 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		890585 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Rn
		222445 CSK_RAT (2-139): 1.11e-23: 99.4: 35.57		PTEN_RAT (118-478): 7.3e-114: 365: 24.37
+	Hs
		433303 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Rn
		222449 SRC_RAT (117-215): 2.55e-11: 64.2: 20.79		PTEN_RAT (118-478): 7.3e-114: 365: 24.37
+	Hs
		789107 FRK_HUMAN (150-212): 6.98e-11: 62.7: 27.78		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Hs
		433843 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		TPTE2_HUMAN (106-424): 9.56e-105: 345: 25.37
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Dm
		1360391 SRC42_DROME (131-215): 1.35e-11: 65: 19.54		Q9VGK8_DROME (804-1253): 9.26e-43: 171: 14.82
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		411823 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ASPP1_HUMAN (749-1169): 6.23e-10: 66.1: 12.59
+	Hs
		297808 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		K0754_HUMAN (949-1350): 3.11e-26: 120: 11.72
+	Hs
		433560 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		522749 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		782828 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		TENS1_HUMAN (427-1338): 2.81e-12: 74: 11.34
+	Hs
		64077 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		L37A2_HUMAN (433-1142): 8.64e-12: 72.4: 9.19
+	Hs
		433948 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ASPP1_HUMAN (749-1169): 6.23e-10: 66.1: 12.59