HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RAI14 (Q9P0K7)
Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)
Gene: RAI14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005938 - cell cortex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 980
+	Hs
		924736 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MY18A_HUMAN (351-942): 3.03e-73: 267: 19.06
+	Hs
		411877 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RAI14_HUMAN (1-980): 4.28e-77: 274: 100.00
+	Hs
		924794 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EHMT2_HUMAN (57-424): 2.35e-45: 180: 14.71
+	Hs
		924844 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		UACA_HUMAN (411-974): 2.3e-39: 161: 24.63
+	Hs
		1078921 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		RAI14_HUMAN (1-980): 4.28e-77: 274: 100.00
+	Hs
		412287 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MY18A_HUMAN (351-942): 3.03e-73: 267: 19.06
+	Hs
		411697 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ANK3_HUMAN (24-405): 2.11e-47: 187: 18.74
+	Hs
		1164359 Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37		POTEE_HUMAN (16-586): 7.23e-65: 239: 18.85
+	Hs
		548727 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		POTEE_HUMAN (16-586): 7.23e-65: 239: 18.85
+	Hs
		257713 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		ANR17_HUMAN (3-464): 1.19e-59: 226: 18.30
+	Hs
		1078859 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		MIB1_HUMAN (1-552): 5.8e-59: 221: 18.56
+	Hs
		557772 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		EHMT2_HUMAN (57-424): 2.35e-45: 180: 14.71
+	Hs
		433730 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ANK3_HUMAN (24-405): 2.11e-47: 187: 18.74
+	Hs
		411590 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		BCL3_HUMAN (34-213): 6.19e-20: 95.9: 32.97
+	Hs
		433986 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		UACA_HUMAN (411-974): 2.3e-39: 161: 24.63
+	Hs
		337406 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DAPK1_HUMAN (111-426): 2.39e-29: 128: 12.03
+	Hs
		411684 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		NOTC2_HUMAN (10-123): 1.42e-14: 81.1: 22.61
+	Hs
		411885 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		KDIS_HUMAN (160-403): 1.98e-12: 73.9: 16.39
+	Hs
		412002 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		BCL3_HUMAN (34-213): 6.19e-20: 95.9: 32.97
+	Hs
		433715 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		NOTC2_HUMAN (10-123): 1.42e-14: 81.1: 22.61