HitPredict

Interactor 1: GRB2 (P62994)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: UBC (Q63429)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]
Gene: UBC

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22871113
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin
Common GO terms	GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 217 Rn			1 810
+	Rn
		1144043 FYN_RAT (161-215): 4.44e-14: 72.3: 31.58		UBC_RAT (1-810): 0: 1000: 100.00
+	Rn
		1144206 FGR_RAT (161-215): 6.67e-12: 65.7: 33.33		UBC_RAT (1-810): 0: 1000: 100.00
+	Rn
		989765 LYN_RAT (129-215): 4.14e-11: 63.4: 23.60		UBC_RAT (1-810): 0: 1000: 100.00
+	Hs
		475592 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		411563 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		337319 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		476483 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475816 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475292 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		923946 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Hs
		474986 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		UBB_HUMAN (1-77): 1.17e-26: 110: 98.70
+	Hs
		557653 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Mm
		70590 B2RR82_MOUSE (2-61): 2.9e-14: 73.1: 35.00		UBC_MOUSE (1-108): 6.19e-31: 132: 90.74
+	Mm
		477062 ITSN1_MOUSE (137-216): 1.77e-12: 67.7: 25.00		UBC_MOUSE (1-108): 6.19e-31: 132: 90.74