Protein: ADA2
SAGA complex subunit ADA2 (Transcriptional adapter 2)

Gene: ADA2
Organism: Saccharomyces cerevisiae S288C
Interactions: 199
UniProt ID: Q02336

Gene Ontology (top 5):
GO:0000124 - SAGA complex
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0001786 - phosphatidylserine binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1036333

GCN5
Histone acetyltransferase GCN5

41

20

Small-scale

0.995

High

1036326

ADA2
SAGA complex subunit ADA2

3

16

Small-scale

0.847

High

738173

NGG1
SAGA complex subunit NGG1

32

3

Small-scale

0.769

High

763009

SPT7
SAGA complex subunit SPT7

28

20

Small-scale

0.768

High

793975

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

20

16

Small-scale

0.764

High

805209

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

17

7

Small-scale

0.764

High

916590

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

19

4

Small-scale

0.764

High

449466

SPT3
SAGA complex subunit SPT3

17

4

Small-scale

0.763

High

893328

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

17

9

Small-scale

0.763

High

1036336

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

17

5

Small-scale

0.762

High

1036355

HFI1
SAGA complex subunit HFI1

14

2

Small-scale

0.762

High

807260

SPT8
SAGA complex subunit SPT8

14

1

Small-scale

0.761

High

917854

SGF73
SAGA complex subunit SGF73

14

5

Small-scale

0.761

High

1036354

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

14

5

Small-scale

0.760

High

676670

SGF29
SAGA complex subunit SGF29

12

6

Small-scale

0.757

High

1036344

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

10

8

Small-scale

0.753

High

1036368

SUS1
SAGA complex subunit SUS1

8

3

Small-scale

0.748

High

898185

SPT20
SAGA complex subunit SPT20

18

0

Small-scale

0.732

High

1036331

SGF11
SAGA complex subunit SGF11

9

0

Small-scale

0.717

High

858457

TAF1
Transcription initiation factor TFIID subunit 1

4

2

Small-scale

0.694

High

561513

TBP
TATA-box-binding protein

4

3

Small-scale

0.681

High

395261

GCN4
General control transcription factor GCN4

4

0

Small-scale

0.669

High

700134

PRP45
Pre-mRNA-processing protein 45

1

3

High-throughput

0.656

High

408433

GAL4
Regulatory protein GAL4

3

4

Small-scale

0.651

High

963659

H3
Histone H3

3

10

Small-scale

0.650

High

1036363

AHC1
Protein AHC1

3

0

Small-scale

0.647

High

678844

AHC2
ADA histone acetyltransferase complex component 2

3

0

High-throughput

0.634

High

1036351

MED7
Mediator of RNA polymerase II transcription subunit 7

2

3

High-throughput

0.621

High

763978

SPT10
Protein SPT10

1

2

High-throughput

0.618

High

524891

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.601

High

626533

AP1
AP-1-like transcription factor YAP1

2

1

High-throughput

0.601

High

740470

MED22
Mediator of RNA polymerase II transcription subunit 22

2

0

High-throughput

0.595

High

1036349

THP1
Nuclear mRNA export protein THP1

2

0

Small-scale

0.585

High

734461

BTAF1
TATA-binding protein-associated factor MOT1

2

20

Small-scale

0.584

High

643276

BAS1
Myb-like DNA-binding protein BAS1

1

10

High-throughput

0.575

High

739906

RPD3
Histone deacetylase RPD3

1

4

High-throughput

0.575

High

402096

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

4

Small-scale

0.571

High

419488

H2A1
Histone H2A.1

2

7

Small-scale

0.571

High

739732

SPT16
FACT complex subunit SPT16

2

1

High-throughput

0.571

High

817022

SPC25
Kinetochore protein SPC25

2

0

High-throughput

0.570

High

811229

PCF11
Protein PCF11

2

0

High-throughput

0.565

High

858348

SAC3
Nuclear mRNA export protein SAC3

2

0

Small-scale

0.559

High

545957

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.552

High

359052

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.536

High

402238

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

4

High-throughput

0.536

High

679987

CDC48
Cell division control protein 48

1

1

High-throughput

0.536

High

709935

BMH1
Protein BMH1

1

4

High-throughput

0.536

High

722184

XPO1
Exportin-1

1

2

High-throughput

0.536

High

760330

BMH2
Protein BMH2

1

4

High-throughput

0.536

High

794754

RTG3
Retrograde regulation protein 3

1

1

High-throughput

0.536

High

1036348

SUB2
ATP-dependent RNA helicase SUB2

1

4

High-throughput

0.536

High

1036364

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.536

High

1027260

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

5

Small-scale

0.529

High

438160

NOT2
General negative regulator of transcription subunit 2

1

1

Small-scale

0.518

High

564671

STE12
Protein STE12

1

0

High-throughput

0.513

High

649236

SAN1
Protein SAN1

1

0

High-throughput

0.513

High

779096

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.513

High

822427

PRS4
26S proteasome regulatory subunit 4 homolog

1

0

High-throughput

0.513

High

1036332

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

High-throughput

0.513

High

1036361

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.513

High

812163

IFH1
Protein IFH1

1

1

Small-scale

0.501

High

427741

RLA2
Large ribosomal subunit protein P2A

1

1

High-throughput

0.489

High

510744

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.489

High

821985

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.486

High

863124

RRP41
Exosome complex component SKI6

1

0

High-throughput

0.486

High

864921

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.486

High

919332

BTN2
Protein BTN2

1

0

High-throughput

0.486

High

1036329

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

1

0

High-throughput

0.486

High

1036334

VPS71
Vacuolar protein sorting-associated protein 71

1

0

High-throughput

0.486

High

1036340

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.486

High

1036346

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.486

High

735540

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

Small-scale

0.480

High

359322

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

Small-scale

0.479

High

444792

SIR2
NAD-dependent histone deacetylase SIR2

1

5

Small-scale

0.479

High

452756

ADR1
Regulatory protein ADR1

1

1

Small-scale

0.479

High

707947

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

735122

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

736707

ASF1
Histone chaperone ASF1

1

3

Small-scale

0.479

High

737931

HOG1
Mitogen-activated protein kinase HOG1

1

4

Small-scale

0.479

High

744331

CHD1
Chromo domain-containing protein 1

1

14

Small-scale

0.479

High

800751

RCK1
Serine/threonine-protein kinase RCK1

1

3

High-throughput

0.479

High

924996

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

1036338

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

1036342

POB3
FACT complex subunit POB3

1

2

High-throughput

0.479

High

1036350

REXO4
RNA exonuclease 4

1

1

Small-scale

0.479

High

1036353

CTI6
Histone deacetylase complex subunit CTI6

1

2

Small-scale

0.479

High

1036357

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

747155

RT04
Small ribosomal subunit protein uS2m

1

2

High-throughput

0.464

High

803526

YHI2
Uncharacterized protein YHR022C

1

2

High-throughput

0.464

High

915380

VPS4
Vacuolar protein sorting-associated protein 4

1

1

High-throughput

0.464

High

1036362

HSP42
Heat shock protein 42

1

1

High-throughput

0.464

High

150303

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.458

High

865711

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

1036366

NOT5
General negative regulator of transcription subunit 5

1

0

Small-scale

0.458

High

381219

H2B1
Histone H2B.1

1

14

Small-scale

0.445

High

381604

H2B2
Histone H2B.2

1

14

Small-scale

0.445

High

419842

H2A2
Histone H2A.2

1

7

High-throughput

0.445

High

436496

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.445

High

448212

HAP2
Transcriptional activator HAP2

1

4

High-throughput

0.445

High

470578

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

3

High-throughput

0.445

High

481732

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

504608

YL12B
Transposon Ty1-LR2 Gag-Pol polyprotein

1

2

High-throughput

0.445

High

590703

HSP26
Heat shock protein 26

1

1

High-throughput

0.445

High

597248

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

645636

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

650007

SIN3
Transcriptional regulatory protein SIN3

1

4

High-throughput

0.445

High

694624

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.445

High

754179

MSN2
Zinc finger protein MSN2

1

7

High-throughput

0.445

High

754238

MSN4
Zinc finger protein MSN4

1

6

High-throughput

0.445

High

763485

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.445

High

781787

SET3
SET domain-containing protein 3

1

8

High-throughput

0.445

High

801159

MED31
Mediator of RNA polymerase II transcription subunit 31

1

4

High-throughput

0.445

High

816540

SNU13
13 kDa ribonucleoprotein-associated protein

1

1

High-throughput

0.445

High

817932

IMB4
Importin subunit beta-4

1

3

High-throughput

0.445

High

1035314

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

20

High-throughput

0.445

High

1036337

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.445

High

1036343

RCO1
Transcriptional regulatory protein RCO1

1

14

High-throughput

0.445

High

1036356

YG11B
Transposon Ty1-GR1 Gag-Pol polyprotein

1

2

High-throughput

0.445

High

1036358

MAK21
Ribosome biogenesis protein MAK21

1

1

High-throughput

0.445

High

1036359

HAL9
Halotolerance protein 9

1

4

High-throughput

0.445

High

1036360

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.445

High

690742

DPB3
DNA polymerase epsilon subunit C

1

0

High-throughput

0.438

High

812585

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

358312

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

572637

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

584934

TRM1
tRNA

1

0

High-throughput

0.426

High

625973

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.426

High

671691

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.426

High

797236

CCZ1
Vacuolar fusion protein CCZ1

1

0

High-throughput

0.426

High

813646

NUP60
Nucleoporin NUP60

1

0

High-throughput

0.426

High

828504

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.426

High

1027367

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.426

High

1036330

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.426

High

1036367

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.426

High

1036352

SOG2
Leucine-rich repeat-containing protein SOG2

1

2

High-throughput

0.417

High

359517

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.407

High

383181

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.407

High

394834

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.407

High

427411

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

453752

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.407

High

518372

IF4A
ATP-dependent RNA helicase eIF4A

1

4

High-throughput

0.407

High

577332

NSP1
Nucleoporin NSP1

1

1

High-throughput

0.407

High

579925

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.407

High

597541

EF3A
Elongation factor 3A

1

1

High-throughput

0.407

High

603533

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.407

High

704797

MSP1
Outer mitochondrial transmembrane helix translocase

1

1

High-throughput

0.407

High

734186

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

736130

ARP2
Actin-related protein 2

1

9

High-throughput

0.407

High

738422

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.407

High

811020

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.407

High

815841

BEM2
GTPase-activating protein BEM2/IPL2

1

4

High-throughput

0.407

High

836854

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

917459

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

3

High-throughput

0.407

High

1028019

ACAC
Acetyl-CoA carboxylase

1

2

High-throughput

0.407

High

1036335

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.407

High

1036341

RBA50
RNA polymerase II-associated protein RBA50

1

1

High-throughput

0.407

High

1036365

NOP58
Nucleolar protein 58

1

2

High-throughput

0.407

High

865045

TCPQ
T-complex protein 1 subunit theta

2

0

High-throughput

0.313

High

386829

TBB
Tubulin beta chain

1

0

High-throughput

0.279

Low

445364

CDC31
Cell division control protein 31

1

0

Small-scale

0.279

Low

502748

RS21A
Small ribosomal subunit protein eS21A

1

0

High-throughput

0.279

Low

609237

CLC1
Clathrin light chain

1

0

High-throughput

0.279

Low

626861

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.279

Low

639453

DIT1
Spore wall maturation protein DIT1

1

0

High-throughput

0.279

Low

746752

KPR1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.279

Low

779437

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

868439

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.279

Low

919478

TIM13
Mitochondrial import inner membrane translocase subunit TIM13

1

0

High-throughput

0.279

Low

673339

TRX3
Thioredoxin-3, mitochondrial

1

0

High-throughput

0.265

Low

813961

RBG1
Ribosome-interacting GTPase 1

1

0

High-throughput

0.265

Low

858548

AP3B
AP-3 complex subunit beta

1

0

High-throughput

0.265

Low

864401

BIT61
Target of rapamycin complex 2 subunit BIT61

1

0

High-throughput

0.265

Low

865207

MRX12
MIOREX complex component 12

1

0

High-throughput

0.265

Low

1036327

YP077
Uncharacterized protein YPL077C

1

0

High-throughput

0.265

Low

1036328

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

0

High-throughput

0.265

Low

314903

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.249

Low

513749

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

514347

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

836230

MID1
Stretch-activated cation channel MID1

1

0

Small-scale

0.249

Low

1036339

GIS4
Protein GIS4

1

0

High-throughput

0.249

Low

1036347

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

417168

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.232

Low

427602

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.232

Low

477615

MYO1
Myosin-1

1

0

High-throughput

0.232

Low

569848

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

575503

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

599063

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.232

Low

605338

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

656342

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

0

High-throughput

0.232

Low

723203

ATP7
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.232

Low

751466

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.232

Low

760617

TSA1
Peroxiredoxin TSA1

1

0

High-throughput

0.232

Low

793344

SYG
Glycine--tRNA ligase 1, mitochondrial

1

0

High-throughput

0.232

Low

793394

ATG42
Vacuolar serine-type carboxypeptidase ATG42

1

0

High-throughput

0.232

Low

820355

YNU8
Uncharacterized protein YNL208W

1

0

High-throughput

0.232

Low

924285

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.232

Low

1036345

NGK1
N-acetylglucosamine kinase

1

0

High-throughput

0.232

Low

1036369

MPD2
Protein disulfide isomerase MPD2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025