HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: GABP1 (Q06547)
GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) (Nuclear respiratory factor 2) (Transcription factor E4TF1-47) (Transcription factor E4TF1-53)
Gene: GABPB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005634 - nucleus GO:0036464 - cytoplasmic ribonucleoprotein granule
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 395
+	Hs
		925204 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ANK2_HUMAN (78-390): 1.79e-61: 216: 14.78
+	Hs
		925723 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		564734 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		545696 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		1330985 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		892676 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		951454 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		894580 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		901042 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		900896 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		Q9H4D1_HUMAN (2-166): 2.6e-43: 162: 32.93
+	Hs
		436568 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		KDIS_HUMAN (1-189): 1.48e-43: 164: 25.79
+	Hs
		883465 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		RIPK4_HUMAN (2-167): 6.14e-41: 156: 32.74
+	Hs
		925593 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TANC1_HUMAN (10-151): 4.4e-15: 79.3: 34.97
+	Hs
		1319199 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		TANC1_HUMAN (10-151): 4.4e-15: 79.3: 34.97
+	Hs
		925238 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ANK3_HUMAN (288-395): 2.96e-10: 64.6: 7.27
+	Hs
		892579 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		TANC1_HUMAN (10-151): 4.4e-15: 79.3: 34.97
+	Hs
		951308 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		TANC1_HUMAN (10-151): 4.4e-15: 79.3: 34.97
+	Hs
		950953 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		ANK3_HUMAN (288-395): 2.96e-10: 64.6: 7.27
+	Hs
		893947 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		ANK3_HUMAN (288-395): 2.96e-10: 64.6: 7.27
+	Hs
		900423 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		ANK3_HUMAN (288-395): 2.96e-10: 64.6: 7.27