HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.878

The method score is based on:

Property Details
Experiments 11130063, 11595749, 32203420, 31871319
Identification Methods x-ray crystallography, pull down, fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PDZ~Ras, PH~Ras, RBD~Ras, Ras~RhoGEF
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007160 - cell-matrix adhesion
GO:0007264 - small GTPase-mediated signal transduction
GO:0016477 - cell migration
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 192
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024