HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: SH3R3 (Q8TEJ3)
E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)
Gene: SH3RF3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.50	0.538

Property	Details
Experiments	20696164
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, solid phase assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 882
+	Hs
		925396 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SH3R1_HUMAN (46-882): 1.03e-98: 330: 42.17
+	Hs
		925289 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG6_HUMAN (769-882): 3.47e-19: 94.9: 19.30
+	Gg
		1141019 Q6LC82_CHICK (1-192): 3.81e-86: 253: 100.00		ARHG6_CHICK (782-882): 1e-18: 93.3: 21.36
+	Hs
		564535 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG6_HUMAN (769-882): 3.47e-19: 94.9: 19.30
+	Hs
		545388 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		ARHG6_HUMAN (769-882): 3.47e-19: 94.9: 19.30
+	Hs
		925271 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Hs
		564524 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Hs
		1066050 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ARHG6_HUMAN (769-882): 3.47e-19: 94.9: 19.30
+	Hs
		925459 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SH3R2_HUMAN (688-882): 4.63e-14: 78.3: 14.36
+	Hs
		545368 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Hs
		925265 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SPTN1_HUMAN (652-882): 1.46e-12: 74.1: 13.79
+	Hs
		564519 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		SPTN1_HUMAN (652-882): 1.46e-12: 74.1: 13.79
+	Hs
		1049733 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Hs
		925374 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DNMBP_HUMAN (666-881): 2.63e-10: 66.6: 10.22
+	Hs
		545364 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		SPTN1_HUMAN (652-882): 1.46e-12: 74.1: 13.79
+	Hs
		925717 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PACN3_HUMAN (762-880): 4.09e-10: 65.1: 20.00
+	Hs
		564730 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PACN3_HUMAN (762-880): 4.09e-10: 65.1: 20.00
+	Hs
		1045519 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		SPTN1_HUMAN (652-882): 1.46e-12: 74.1: 13.79
+	Hs
		950981 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		SPTN1_HUMAN (652-882): 1.46e-12: 74.1: 13.79
+	Hs
		1330981 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		PACN3_HUMAN (762-880): 4.09e-10: 65.1: 20.00