Protein: RCM1
25S rRNA (cytosine(2278)-C(5))-methyltransferase (EC 2.1.1.311) (rRNA m(5)C methyltransferase 1)

Gene: RCM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 76
UniProt ID: P53972

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0009383 - rRNA (cytosine-C5-)-methyltransferase activity
GO:0070475 - rRNA base methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

918946

PESC
Pescadillo homolog

3

2

High-throughput

0.640

High

830157

NOP2
25S rRNA

1

5

High-throughput

0.618

High

925449

NOC3
Nucleolar complex-associated protein 3

1

4

High-throughput

0.618

High

925454

NIP7
60S ribosome subunit biogenesis protein NIP7

1

3

High-throughput

0.618

High

917542

NSA1
Ribosome biogenesis protein NSA1

2

2

High-throughput

0.584

High

782405

RPF2
Ribosome biogenesis protein RPF2

2

3

High-throughput

0.571

High

722164

XPO1
Exportin-1

1

2

High-throughput

0.536

High

754508

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.515

High

656579

KC11
Casein kinase I homolog 1

1

3

High-throughput

0.501

High

656840

KC12
Casein kinase I homolog 2

1

3

High-throughput

0.501

High

801891

KSP1
Serine/threonine-protein kinase KSP1

1

3

High-throughput

0.501

High

925443

STE20
Serine/threonine-protein kinase STE20

1

3

High-throughput

0.501

High

925459

SKM1
Serine/threonine-protein kinase SKM1

1

2

High-throughput

0.501

High

925460

SKS1
Serine/threonine-protein kinase SKS1

1

3

High-throughput

0.501

High

813391

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.493

High

778915

NNK1
Nitrogen network kinase 1

1

0

High-throughput

0.480

High

149895

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

410272

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

433781

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

435275

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

436100

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

442052

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

455200

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

512584

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.479

High

674766

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

677226

SPB1
27S pre-rRNA

1

5

High-throughput

0.479

High

682359

SPB4
ATP-dependent rRNA helicase SPB4

1

10

High-throughput

0.479

High

689596

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

707871

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

735101

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

746655

DRS1
ATP-dependent RNA helicase DRS1

1

10

High-throughput

0.479

High

750124

MRT4
Ribosome assembly factor MRT4

1

5

High-throughput

0.479

High

763102

RRP1
Ribosomal RNA-processing protein 1

1

5

High-throughput

0.479

High

778473

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

780299

EBP2
rRNA-processing protein EBP2

1

3

High-throughput

0.479

High

795836

YBC8
UPF0642 protein YBL028C

1

1

High-throughput

0.479

High

803907

CIC1
Proteasome-interacting protein CIC1

1

2

High-throughput

0.479

High

805075

RPF1
Ribosome production factor 1

1

4

High-throughput

0.479

High

814361

NOC2
Nucleolar complex protein 2

1

2

High-throughput

0.479

High

816784

NOP16
Nucleolar protein 16

1

1

High-throughput

0.479

High

816882

NUG1
Nuclear GTP-binding protein NUG1

1

4

High-throughput

0.479

High

818261

NSA2
Ribosome biogenesis protein NSA2

1

2

High-throughput

0.479

High

827577

RLP7
Ribosome biogenesis protein RLP7

1

4

High-throughput

0.479

High

850002

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

1

High-throughput

0.479

High

923053

TR112
Multifunctional methyltransferase subunit TRM112

1

1

Small-scale

0.479

High

924828

NOP15
Ribosome biogenesis protein 15

1

3

High-throughput

0.479

High

925439

H3
Histone H3

1

5

High-throughput

0.479

High

925441

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

925442

NOG1
Nucleolar GTP-binding protein 1

1

3

High-throughput

0.479

High

925444

HAS1
ATP-dependent RNA helicase HAS1

1

13

High-throughput

0.479

High

925445

RRB1
Ribosome assembly protein RRB1

1

7

High-throughput

0.479

High

925446

PUF6
Pumilio homology domain family member 6

1

2

High-throughput

0.479

High

925447

ERB1
Ribosome biogenesis protein ERB1

1

5

High-throughput

0.479

High

925450

NOP12
Nucleolar protein 12

1

5

High-throughput

0.479

High

925451

BRX1
Ribosome biogenesis protein BRX1

1

16

High-throughput

0.479

High

925452

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

925453

RRS1
Regulator of ribosome biosynthesis

1

3

High-throughput

0.479

High

925455

YTM1
Ribosome biogenesis protein YTM1

1

8

High-throughput

0.479

High

925456

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

1

High-throughput

0.479

High

925457

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.479

High

925458

DBP10
ATP-dependent RNA helicase DBP10

1

9

High-throughput

0.479

High

704695

PRR1
Serine/threonine-protein kinase PRR1

1

1

High-throughput

0.457

High

925440

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

3

High-throughput

0.457

High

527400

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

819471

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

925448

FKBP4
FK506-binding protein 4

1

5

High-throughput

0.445

High

383834

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

504354

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

513152

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

514772

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

579870

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

747515

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

753518

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

802315

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

812550

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

874461

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025