HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: ARHGQ (Q96DR7)
Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)
Gene: ARHGEF26

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0097178 - ruffle assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 871
+	Hs
		925436 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		NGEF_HUMAN (176-868): 2.83e-113: 364: 26.96
+	Hs
		164115 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGA_HUMAN (69-758): 2.51e-95: 328: 18.40
+	Hs
		925416 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGJ_HUMAN (69-864): 5.56e-94: 315: 23.90
+	Hs
		925527 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SPT13_HUMAN (230-789): 1.15e-94: 313: 16.07
+	Hs
		925649 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG4_HUMAN (182-815): 5.85e-89: 298: 15.30
+	Hs
		166482 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MCF2L_HUMAN (175-851): 1.06e-84: 296: 13.99
+	Hs
		925382 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX2_HUMAN (429-793): 1.75e-83: 295: 19.21
+	Hs
		500934 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MCF2_HUMAN (176-858): 1.78e-85: 294: 13.92
+	Hs
		925455 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX1_HUMAN (391-824): 9.37e-82: 290: 18.50
+	Ce
		975575 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		VAV_CAEEL (348-821): 5.33e-85: 294: 17.77
+	Hs
		925760 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FARP1_HUMAN (217-863): 5.87e-79: 278: 15.16
+	Hs
		564756 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		FARP1_HUMAN (217-863): 5.87e-79: 278: 15.16
+	Hs
		925624 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ECT2_HUMAN (262-825): 3.77e-78: 274: 16.29
+	Hs
		548678 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV_HUMAN (376-806): 2.68e-78: 273: 16.20
+	Hs
		855782 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV2_HUMAN (362-796): 4.52e-77: 270: 17.24
+	Hs
		545718 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		FARP1_HUMAN (217-863): 5.87e-79: 278: 15.16
+	Dm
		776905 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		Q9U7D8_DROME (430-699): 6.24e-73: 258: 21.46
+	Hs
		224711 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KALRN_HUMAN (424-866): 8.06e-63: 233: 14.51
+	Hs
		167081 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGB_HUMAN (433-641): 1.28e-10: 67.8: 22.94
+	Hs
		279854 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TRIO_HUMAN (23-231): 4.97e-09: 62.4: 14.83