HitPredict

Interactor 1: VAMP2 (P63027)
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene: VAMP2

Interactor 2: STX19 (Q8N4C7)
Syntaxin-19
Gene: STX19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0006887 - exocytosis GO:0008021 - synaptic vesicle and 1 others more... GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 116 Hs			1 294
+	Rn
		699183 VAMP7_RAT (3-97): 1.33e-30: 110: 32.00		STX1A_RAT (8-288): 2.27e-68: 215: 29.08
+	Dm
		1098086 Q7JYX5_DROME (6-111): 3.92e-34: 118: 23.42		STX1A_DROME (28-289): 4.7e-64: 204: 25.10
+	Dm
		577220 SYB_DROME (1-115): 4.95e-33: 114: 51.91		STX1A_DROME (28-289): 4.7e-64: 204: 25.10
+	At
		812702 VA722_ARATH (4-96): 1.02e-38: 130: 30.30		SY121_ARATH (20-283): 1.04e-54: 182: 16.54
+	At
		1378372 VA721_ARATH (4-96): 3.94e-38: 129: 30.30		SY121_ARATH (20-283): 1.04e-54: 182: 16.54
+	At
		1352937 VA721_ARATH (4-96): 3.94e-38: 129: 30.30		SY122_ARATH (5-283): 2.39e-54: 181: 16.73
+	At
		1352876 VA721_ARATH (4-96): 3.94e-38: 129: 30.30		SYP43_ARATH (12-291): 3.34e-49: 167: 11.50
+	At
		249598 VA721_ARATH (4-96): 3.94e-38: 129: 30.30		SYP41_ARATH (12-291): 3.82e-49: 167: 11.85
+	At
		812689 VA722_ARATH (4-96): 1.02e-38: 130: 30.30		SY111_ARATH (13-283): 6.95e-47: 161: 15.11
+	At
		1114744 VA721_ARATH (4-96): 3.94e-38: 129: 30.30		SY111_ARATH (13-283): 6.95e-47: 161: 15.11
+	At
		955702 VA721_ARATH (4-96): 3.94e-38: 129: 30.30		SYP22_ARATH (58-287): 3.13e-46: 158: 16.24
+	At
		1258650 VA721_ARATH (4-96): 3.94e-38: 129: 30.30		SY132_ARATH (30-283): 3.85e-45: 156: 18.70
+	At
		1352985 VA721_ARATH (4-96): 3.94e-38: 129: 30.30		SYP42_ARATH (12-291): 9.88e-45: 156: 12.15
+	At
		955681 VA713_ARATH (8-113): 8.5e-36: 123: 23.42		SYP22_ARATH (58-287): 3.13e-46: 158: 16.24
+	At
		955679 VA714_ARATH (8-114): 7.02e-35: 120: 25.89		SYP22_ARATH (58-287): 3.13e-46: 158: 16.24
+	Dm
		1178106 Q7JYX5_DROME (6-111): 3.92e-34: 118: 23.42		STX4_DROME (34-284): 9.59e-45: 156: 15.54
+	Dm
		1178130 Q7JYX5_DROME (6-111): 3.92e-34: 118: 23.42		Q9VR90_DROME (4-287): 2.29e-44: 155: 10.94
+	At
		221561 VA711_ARATH (7-114): 2.31e-31: 112: 23.89		SYP22_ARATH (58-287): 3.13e-46: 158: 16.24
+	Dm
		577227 SYB_DROME (1-115): 4.95e-33: 114: 51.91		STX4_DROME (34-284): 9.59e-45: 156: 15.54
+	Dm
		577251 SYB_DROME (1-115): 4.95e-33: 114: 51.91		Q9VR90_DROME (4-287): 2.29e-44: 155: 10.94