HitPredict

Interactor 1: CANB1 (P63098)
Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Gene: PPP3R1

Interactor 2: RCAN3 (Q9UKA8)
Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3)
Gene: RCAN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008597 - calcium-dependent protein serine/threonine phosphatase regulator activity GO:0019902 - phosphatase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 170 Hs			1 241
+	Hs
		926734 CANB1_HUMAN (1-170): 3.82e-49: 158: 100.00		RCAN2_HUMAN (38-232): 8.72e-104: 300: 67.86
+	Hs
		865103 CANB1_HUMAN (1-170): 3.82e-49: 158: 100.00		RCAN1_HUMAN (38-228): 1.19e-100: 294: 60.20
+	Hs
		865114 CANB2_HUMAN (1-170): 5.69e-44: 144: 84.71		RCAN1_HUMAN (38-228): 1.19e-100: 294: 60.20
+	Dm
		1096818 CANB2_DROME (1-170): 2.22e-46: 151: 87.65		SRA_DROME (30-225): 3.11e-81: 246: 41.79
+	Hs
		483987 CALM2_HUMAN (86-159): 2.91e-10: 57.2: 27.03		RCAN1_HUMAN (38-228): 1.19e-100: 294: 60.20
+	Hs
		484089 CALM3_HUMAN (86-159): 2.91e-10: 57.2: 27.03		RCAN1_HUMAN (38-228): 1.19e-100: 294: 60.20
+	Dm
		906754 CALM_DROME (86-159): 3.94e-10: 56.8: 27.03		SRA_DROME (30-225): 3.11e-81: 246: 41.79