Protein: S22A5
Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5)

Gene: S22A5, SLC22A5
Organism: Homo sapiens
Interactions: 110
UniProt ID: O76082

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

303283

S22A4
Solute carrier family 22 member 4

2

5

High-throughput

0.776

High

303252

S22A9
Organic anion transporter 7

2

6

High-throughput

0.726

High

303282

YIPF3
Protein YIPF3

4

2

High-throughput

0.687

High

303228

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

2

1

High-throughput

0.621

High

303239

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

4

High-throughput

0.611

High

303238

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.606

High

170590

CLGN
Calmegin

2

9

High-throughput

0.601

High

300272

KRT34
Keratin, type I cuticular Ha4

2

0

High-throughput

0.580

High

303247

K1C27
Keratin, type I cytoskeletal 27

2

0

High-throughput

0.580

High

303298

AMFR
E3 ubiquitin-protein ligase AMFR

2

9

High-throughput

0.552

High

303221

NEK4
Serine/threonine-protein kinase Nek4

1

2

High-throughput

0.536

High

303223

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.536

High

303234

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

303246

NT2NA
Notch homolog 2 N-terminal-like protein A

1

7

High-throughput

0.481

High

303248

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

2

High-throughput

0.481

High

303209

RASK
GTPase KRas

1

6

High-throughput

0.479

High

303214

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.479

High

303224

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

303226

RHOB
Rho-related GTP-binding protein RhoB

1

9

High-throughput

0.479

High

303300

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

303213

NT2NC
Notch homolog 2 N-terminal-like protein C

1

7

High-throughput

0.470

High

452

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.460

High

61068

T131L
Transmembrane protein 131-like

1

3

High-throughput

0.445

High

71047

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

4

High-throughput

0.445

High

161177

EI24
Etoposide-induced protein 2.4 homolog

1

1

High-throughput

0.445

High

181216

PGRC2
Membrane-associated progesterone receptor component 2

1

7

High-throughput

0.445

High

184090

RER1
Protein RER1

1

2

High-throughput

0.445

High

184359

SURF4
Surfeit locus protein 4

1

1

High-throughput

0.445

High

249391

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

5

High-throughput

0.445

High

303207

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

2

High-throughput

0.445

High

303208

CDS2
Phosphatidate cytidylyltransferase 2

1

4

High-throughput

0.445

High

303210

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.445

High

303215

NCPR
NADPH--cytochrome P450 reductase

1

2

High-throughput

0.445

High

303216

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

2

High-throughput

0.445

High

303217

CALX
Calnexin

1

9

High-throughput

0.445

High

303218

HMOX2
Heme oxygenase 2

1

2

High-throughput

0.445

High

303219

PSN2
Presenilin-2

1

1

High-throughput

0.445

High

303222

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

1

High-throughput

0.445

High

303225

SELT
Thioredoxin reductase-like selenoprotein T

1

2

High-throughput

0.445

High

303227

AT2C1
Calcium-transporting ATPase type 2C member 1

1

7

High-throughput

0.445

High

303229

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

3

High-throughput

0.445

High

303230

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.445

High

303231

STAR3
StAR-related lipid transfer protein 3

1

2

High-throughput

0.445

High

303232

TRAM1
Translocating chain-associated membrane protein 1

1

7

High-throughput

0.445

High

303236

YIF1B
Protein YIF1B

1

2

High-throughput

0.445

High

303240

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.445

High

303242

HACD2
Very-long-chain

1

3

High-throughput

0.445

High

303250

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

10

High-throughput

0.445

High

303253

SGPP2
Sphingosine-1-phosphate phosphatase 2

1

3

High-throughput

0.445

High

303255

AN13A
Ankyrin repeat domain-containing protein 13A

1

8

High-throughput

0.445

High

303256

AGRG2
Adhesion G-protein coupled receptor G2

1

5

High-throughput

0.445

High

303259

ATAD1
Outer mitochondrial transmembrane helix translocase

1

4

High-throughput

0.445

High

303264

CDS1
Phosphatidate cytidylyltransferase 1

1

4

High-throughput

0.445

High

303271

VMP1
Vacuole membrane protein 1

1

2

High-throughput

0.445

High

303273

CLP1L
Lipid scramblase CLPTM1L

1

6

High-throughput

0.445

High

303275

SORT
Sortilin

1

2

High-throughput

0.445

High

303276

REEP2
Receptor expression-enhancing protein 2

1

2

High-throughput

0.445

High

303280

TMM43
Transmembrane protein 43

1

2

High-throughput

0.445

High

303281

FUT8
Alpha-(1,6)-fucosyltransferase

1

1

High-throughput

0.445

High

303284

RHBG
Ammonium transporter Rh type B

1

1

High-throughput

0.445

High

303285

FZD8
Frizzled-8

1

3

High-throughput

0.445

High

303288

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

2

High-throughput

0.445

High

303291

RTN4
Reticulon-4

1

4

High-throughput

0.445

High

303292

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

8

High-throughput

0.445

High

303293

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

8

High-throughput

0.445

High

303296

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

5

High-throughput

0.445

High

303297

SE1L1
Protein sel-1 homolog 1

1

4

High-throughput

0.445

High

303301

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

3

High-throughput

0.445

High

303302

UBIA1
UbiA prenyltransferase domain-containing protein 1

1

1

High-throughput

0.445

High

303303

S23IP
SEC23-interacting protein

1

1

High-throughput

0.445

High

303211

B3A2
Anion exchange protein 2

1

0

High-throughput

0.426

High

303260

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.426

High

303267

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.426

High

303270

DAZP1
DAZ-associated protein 1

1

0

High-throughput

0.426

High

303278

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.426

High

303279

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.426

High

303299

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.426

High

186393

TM9S1
Transmembrane 9 superfamily member 1

1

5

High-throughput

0.407

High

223680

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

2

High-throughput

0.407

High

303212

GPHRB
Golgi pH regulator B

1

4

High-throughput

0.407

High

303220

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

3

High-throughput

0.407

High

303233

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

1

High-throughput

0.407

High

303235

TM41B
Transmembrane protein 41B

1

3

High-throughput

0.407

High

303237

RABL3
Rab-like protein 3

1

3

High-throughput

0.407

High

303243

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

4

High-throughput

0.407

High

303244

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

3

High-throughput

0.407

High

303245

D19L4
Probable C-mannosyltransferase DPY19L4

1

2

High-throughput

0.407

High

303249

PIGW
Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

1

4

High-throughput

0.407

High

303254

K2013
Uncharacterized protein KIAA2013

1

1

High-throughput

0.407

High

303257

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.407

High

303258

TTC13
Tetratricopeptide repeat protein 13

1

5

High-throughput

0.407

High

303261

GOGA5
Golgin subfamily A member 5

1

2

High-throughput

0.407

High

303262

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

3

High-throughput

0.407

High

303263

TM131
Transmembrane protein 131

1

4

High-throughput

0.407

High

303265

PIGT
GPI-anchor transamidase component PIGT

1

1

High-throughput

0.407

High

303266

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.407

High

303268

ERLEC
Endoplasmic reticulum lectin 1

1

5

High-throughput

0.407

High

303269

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.407

High

303274

PIGS
GPI-anchor transamidase component PIGS

1

1

High-throughput

0.407

High

303289

TM9S3
Transmembrane 9 superfamily member 3

1

5

High-throughput

0.407

High

303295

T161A
Transmembrane protein 161A

1

3

High-throughput

0.407

High

230688

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

303241

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.232

Low

303251

GP180
Integral membrane protein GPR180

1

0

High-throughput

0.232

Low

303272

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.232

Low

303277

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.232

Low

303286

TRABD
TraB domain-containing protein

1

0

High-throughput

0.232

Low

303287

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.232

Low

303290

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.232

Low

303294

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025