HitPredict

Interactor 1: E9PTY0 (E9PTY0)
Leucine rich repeat and coiled-coil centrosomal protein 1
Gene: Lrrcc1

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	LRR_4~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1010 Rn			1 1383
+	Hs
		411426 LRC49_HUMAN (14-185): 7.78e-48: 184: 33.14		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Rn
		94275 F1LUA1_RAT (1-459): 4.72e-10: 65.9: 8.86		INSR_RAT (1-1383): 0: 1575: 100.00
+	Hs
		537756 LRC49_HUMAN (14-185): 7.78e-48: 184: 33.14		INSRR_HUMAN (12-1339): 0: 1276: 51.80
+	Hs
		435647 EEA1_HUMAN (1-887): 5.27e-36: 150: 8.71		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		665495 LRC49_HUMAN (14-185): 7.78e-48: 184: 33.14		EPHA8_HUMAN (663-1323): 1.14e-174: 548: 22.59
+	Hs
		665407 LRC49_HUMAN (14-185): 7.78e-48: 184: 33.14		EPHA3_HUMAN (661-1320): 4.01e-172: 541: 24.15
+	Hs
		665375 MYH9_HUMAN (48-998): 1.79e-42: 171: 9.93		EPHA3_HUMAN (661-1320): 4.01e-172: 541: 24.15
+	Hs
		1189813 MYH14_HUMAN (412-975): 7.5e-13: 75.3: 14.29		EPHA6_HUMAN (662-1299): 1.62e-175: 552: 21.91
+	Hs
		445856 LRC49_HUMAN (14-185): 7.78e-48: 184: 33.14		ROS1_HUMAN (1020-1292): 1.06e-71: 267: 49.46
+	Hs
		725069 MYH9_HUMAN (48-998): 1.79e-42: 171: 9.93		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Hs
		385122 LRC49_HUMAN (14-185): 7.78e-48: 184: 33.14		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		384384 MYH9_HUMAN (48-998): 1.79e-42: 171: 9.93		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		725268 MYH10_HUMAN (26-802): 1.52e-31: 136: 8.85		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Hs
		384385 MYH10_HUMAN (26-802): 1.52e-31: 136: 8.85		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		609293 EEA1_HUMAN (1-887): 5.27e-36: 150: 8.71		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		338037 MYH9_HUMAN (48-998): 1.79e-42: 171: 9.93		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		383815 EEA1_HUMAN (1-887): 5.27e-36: 150: 8.71		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83