HitPredict

Interactor 1: KCNJ2 (P63252)
Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)
Gene: KCNJ2

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	10627592
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043197 - dendritic spine GO:0045211 - postsynaptic membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 724
+	Hs
		942342 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Rn
		677769 KCJ12_RAT (2-427): 0: 668: 70.33		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		852403 KCNJ4_MOUSE (31-427): 0: 601: 59.64		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		816146 KCNJ4_HUMAN (30-427): 0: 590: 59.82		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		929767 KCNJ2_HUMAN (1-427): 0: 724: 100.00		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		929764 KCNJ2_HUMAN (1-427): 0: 724: 100.00		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Rn
		1144015 KCNJ2_RAT (1-427): 0: 720: 98.83		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Rn
		1144360 KCNJ2_RAT (1-427): 0: 720: 98.83		DLG2_RAT (225-474): 1.48e-18: 92.5: 21.09
+	Hs
		1049947 KCJ12_HUMAN (2-427): 0: 682: 69.98		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		1054729 KCJ12_HUMAN (2-427): 0: 682: 69.98		PALS2_HUMAN (2-203): 5.54e-21: 99.4: 14.42
+	Hs
		1021490 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		159210 KCJ12_HUMAN (2-427): 0: 682: 69.98		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		1054723 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG2_HUMAN (225-474): 2.32e-18: 92.1: 21.09
+	Hs
		80982 KCJ18_HUMAN (2-427): 0: 675: 69.28		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Rn
		852397 KCJ12_RAT (2-427): 0: 668: 70.33		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Rn
		852398 KCJ12_RAT (2-427): 0: 668: 70.33		CSKP_RAT (6-200): 2.45e-19: 95.2: 14.80
+	Hs
		1054724 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58
+	Rn
		852400 KCJ12_RAT (2-427): 0: 668: 70.33		DLG2_RAT (225-474): 1.48e-18: 92.5: 21.09
+	Rn
		852399 KCJ12_RAT (2-427): 0: 668: 70.33		DLG3_RAT (221-548): 5.99e-15: 80.9: 18.55
+	Hs
		159173 KCNJ4_HUMAN (30-427): 0: 590: 59.82		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29