Protein: SYWC
Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]

Gene: SYWC, WARS1
Organism: Homo sapiens
Interactions: 90
UniProt ID: P23381

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0004830 - tryptophan-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

657883

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

5

Small-scale

0.647

High

240771

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

425313

ISG15
Ubiquitin-like protein ISG15

2

4

High-throughput

0.584

High

316750

MTA2
Metastasis-associated protein MTA2

2

1

High-throughput

0.571

High

657893

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

657899

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

0

High-throughput

0.547

High

657889

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.541

High

657914

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

105351

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

657892

DNLI4
DNA ligase 4

1

0

High-throughput

0.529

High

657919

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

608220

EGLN
Endoglin

1

0

High-throughput

0.513

High

657933

DCA13
DDB1- and CUL4-associated factor 13

1

2

High-throughput

0.508

High

657935

DNM3B
DNA

1

1

High-throughput

0.508

High

657887

CADH5
Cadherin-5

1

0

Small-scale

0.505

High

185433

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

421517

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

507533

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

247228

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

4

High-throughput

0.479

High

293206

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

345380

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

352969

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

371178

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

411365

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

486961

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

534643

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

587932

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

606233

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

648088

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.479

High

657885

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

High-throughput

0.479

High

657886

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

657895

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

657896

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

657898

UBE3A
Ubiquitin-protein ligase E3A

1

3

High-throughput

0.479

High

657900

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

657901

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

657902

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

657904

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

657907

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

657909

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

657911

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

657912

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

1

High-throughput

0.479

High

657916

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

657917

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.479

High

657918

OPTN
Optineurin

1

2

High-throughput

0.479

High

657922

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

657923

NECD
Necdin

1

3

High-throughput

0.479

High

657929

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

657930

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

657932

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

657934

DYH9
Dynein axonemal heavy chain 9

1

1

High-throughput

0.479

High

657936

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

657938

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.479

High

657939

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

657942

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

657884

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

657894

CD81
CD81 antigen

1

0

High-throughput

0.458

High

657897

CENPC
Centromere protein C

1

0

High-throughput

0.458

High

657910

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

657913

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.458

High

657915

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

657921

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

657925

SYCP2
Synaptonemal complex protein 2

1

0

High-throughput

0.458

High

657927

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

657928

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

657937

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

657941

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

0

High-throughput

0.458

High

142280

PEX7
Peroxisomal targeting signal 2 receptor

1

3

High-throughput

0.445

High

429313

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

529092

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

563207

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

657905

Q32Q12
Nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

657906

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

657931

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

657940

GAB2
GRB2-associated-binding protein 2

1

3

High-throughput

0.445

High

657908

Q6IAV4
Cyclin-dependent kinase 2-associated protein

1

0

High-throughput

0.438

High

657888

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

657890

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

657903

PTC1
Protein patched homolog 1

1

1

Small-scale

0.437

High

404671

PRIO
Major prion protein

1

0

High-throughput

0.426

High

657891

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

657926

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

249094

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

657924

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

217841

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

276061

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.249

Low

451333

NFM
Neurofilament medium polypeptide

1

0

High-throughput

0.249

Low

261085

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

657920

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025