HitPredict

Interactor 1: ACTG (P63260)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: Actg1

Interactor 2: EED (Q921E6)
Polycomb protein EED
Gene: EED

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	24457600, 20064375
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~WD40
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 375 Mm			1 441
+	Mm
		1206348 ACTBL_MOUSE (1-375): 0: 741: 92.27		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		268014 ACTG_HUMAN (1-375): 0: 604: 100.00		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Mm
		892206 ACTB_MOUSE (1-375): 0: 604: 98.93		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Mm
		932492 ACTC_MOUSE (2-375): 0: 595: 94.39		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		903280 ACTBL_HUMAN (2-375): 0: 734: 91.44		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		903316 POTEE_HUMAN (1-375): 0: 729: 91.47		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		932318 ACTC_HUMAN (2-375): 0: 595: 94.39		SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29
+	Hs
		792947 ACTB_HUMAN (1-375): 0: 604: 98.93		LIS1_HUMAN (332-438): 2.37e-14: 76.5: 18.69
+	Hs
		792968 ACTG_HUMAN (1-375): 0: 604: 100.00		LIS1_HUMAN (332-438): 2.37e-14: 76.5: 18.69
+	Hs
		891660 ACTB_HUMAN (1-375): 0: 604: 98.93		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		903110 ACTG_HUMAN (1-375): 0: 604: 100.00		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Sc
		863622 ACT_YEAST (1-375): 0: 592: 89.07		COPA_YEAST (15-182): 2.3e-11: 68.1: 10.71
+	Hs
		196998 ACTC_HUMAN (2-375): 0: 595: 94.39		PRP4_HUMAN (337-437): 3.12e-09: 60.7: 16.51