HitPredict

Interactor 1: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~HSA, Actin~SNF2-rel_dom
Common GO terms	GO:0005524 - ATP binding GO:0016787 - hydrolase activity GO:0035267 - NuA4 histone acetyltransferase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 3159
+	Hs
		891979 ACTB_HUMAN (1-375): 0: 604: 98.93		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		932332 ACTC_HUMAN (2-375): 0: 595: 94.39		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		229358 ACTC_HUMAN (2-375): 0: 595: 94.39		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Dm
		501486 ACT1_DROME (2-375): 0: 600: 98.13		BRM_DROME (1527-2267): 3.24e-149: 512: 14.69
+	Dm
		361138 ACT2_DROME (2-375): 0: 598: 97.59		BRM_DROME (1527-2267): 3.24e-149: 512: 14.69
+	Hs
		892104 ACTB_HUMAN (1-375): 0: 604: 98.93		INO80_HUMAN (1754-2150): 2.56e-83: 307: 25.38
+	Hs
		1122431 ACTBL_HUMAN (2-375): 0: 734: 91.44		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		846794 ACTBL_HUMAN (2-375): 0: 734: 91.44		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		891853 ACTB_HUMAN (1-375): 0: 604: 98.93		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		929905 ACTG_HUMAN (1-375): 0: 604: 100.00		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		932219 ACTC_HUMAN (2-375): 0: 595: 94.39		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Sp
		142452 ACT_SCHPO (1-375): 0: 594: 91.47		SWR1_SCHPO (1399-1518): 3.27e-15: 84.8: 9.17
+	Mm
		929800 ACTG_MOUSE (1-375): 0: 604: 100.00		EP400_MOUSE (2511-3159): 1.94e-10: 69.5: 10.79
+	Mm
		929795 ACTG_MOUSE (1-375): 0: 604: 100.00		SMCA2_MOUSE (2682-2984): 5.95e-09: 64.5: 13.03
+	Xl
		292752 ACTB_XENLA (1-375): 0: 604: 98.93		Q4VQ79_XENLA (2756-3006): 7.42e-09: 64.1: 13.13
+	Mm
		929785 ACTG_MOUSE (1-375): 0: 604: 100.00		SMCA4_MOUSE (2528-2890): 6.78e-09: 64.1: 11.57
+	Hs
		846910 ACTB_HUMAN (1-375): 0: 604: 98.93		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		846917 ACTG_HUMAN (1-375): 0: 604: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		846742 ACTC_HUMAN (2-375): 0: 595: 94.39		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		846918 ACTC_HUMAN (2-375): 0: 595: 94.39		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17