Protein: ACTN2
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)

Gene: ACTN2
Organism: Homo sapiens
Interactions: 147
UniProt ID: P35609

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

773767

TITIN
Titin

5

20

Small-scale

0.929

High

773707

ACTN2
Alpha-actinin-2

5

14

Small-scale

0.923

High

773748

PDLI3
PDZ and LIM domain protein 3

4

20

High-throughput

0.916

High

773760

MILK2
MICAL-like protein 2

4

16

High-throughput

0.901

High

123228

PDLI1
PDZ and LIM domain protein 1

4

20

Small-scale

0.897

High

648807

KCNA5
Potassium voltage-gated channel subfamily A member 5

3

4

Small-scale

0.884

High

773788

MYOZ2
Myozenin-2

3

7

High-throughput

0.881

High

555622

ACTN1
Alpha-actinin-1

3

14

High-throughput

0.863

High

224640

ACTN4
Alpha-actinin-4

3

14

High-throughput

0.827

High

773732

ACTN3
Alpha-actinin-3

2

14

Small-scale

0.819

High

773715

CSRP3
Cysteine and glycine-rich protein 3

2

16

Small-scale

0.806

High

713071

NOS3
Nitric oxide synthase 3

2

2

Small-scale

0.762

High

773721

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.740

High

648763

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

4

Small-scale

0.713

High

773781

KCNN2
Small conductance calcium-activated potassium channel protein 2

1

4

Small-scale

0.713

High

773787

MYOZ1
Myozenin-1

1

7

Small-scale

0.713

High

773758

NRAP
Nebulin-related-anchoring protein

1

8

Small-scale

0.710

High

773743

SP17
Sperm surface protein Sp17

1

0

High-throughput

0.702

High

773718

MYOM2
Myomesin-2

1

17

High-throughput

0.698

High

773738

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.698

High

773740

MYPC2
Myosin-binding protein C, fast-type

1

15

High-throughput

0.698

High

773779

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

19

High-throughput

0.698

High

349838

SNAI1
Zinc finger protein SNAI1

4

4

High-throughput

0.698

High

659174

SP100
Nuclear autoantigen Sp-100

3

5

High-throughput

0.683

High

773762

SAXO1
Stabilizer of axonemal microtubules 1

3

0

High-throughput

0.654

High

773802

TENN
Tenascin-N

1

12

Small-scale

0.647

High

773741

RTP5
Receptor-transporting protein 5

4

1

High-throughput

0.637

High

773792

DISC1
Disrupted in schizophrenia 1 protein

2

4

Small-scale

0.628

High

773752

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

1

High-throughput

0.625

High

270703

LDB3
LIM domain-binding protein 3

1

16

Small-scale

0.621

High

457055

CAN1
Calpain-1 catalytic subunit

1

2

Small-scale

0.621

High

773728

CAC1D
Voltage-dependent L-type calcium channel subunit alpha-1D

1

3

Small-scale

0.621

High

773726

DLG4
Disks large homolog 4

2

13

Small-scale

0.619

High

364120

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

0

High-throughput

0.619

High

67532

MYH7B
Myosin-7B

1

8

High-throughput

0.618

High

157023

CTRO
Citron Rho-interacting kinase

1

13

High-throughput

0.618

High

773771

IGSF8
Immunoglobulin superfamily member 8

1

10

High-throughput

0.618

High

71797

CMA1B
Ciliary microtubule associated protein 1B

2

1

High-throughput

0.606

High

680793

PSA1
Proteasome subunit alpha type-1

2

1

High-throughput

0.606

High

773786

SYP2L
Synaptopodin 2-like protein

2

20

High-throughput

0.606

High

773747

ZC21C
Zinc finger C2HC domain-containing protein 1C

3

1

High-throughput

0.597

High

773725

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.590

High

773744

ZYX
Zyxin

1

4

Small-scale

0.590

High

773751

FXL22
F-box and leucine-rich protein 22

1

1

Small-scale

0.586

High

773720

ACTB
Actin, cytoplasmic 1

1

13

Small-scale

0.584

High

773770

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.580

High

773773

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

773790

PDLI7
PDZ and LIM domain protein 7

1

20

High-throughput

0.575

High

773753

CDC73
Parafibromin

1

3

Small-scale

0.573

High

229264

ANGL7
Angiopoietin-related protein 7

1

1

High-throughput

0.573

High

773722

H4
Histone H4

1

1

High-throughput

0.573

High

773724

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.573

High

333302

SNAPN
SNARE-associated protein Snapin

1

3

High-throughput

0.568

High

397910

ANGI
Angiogenin

1

0

Small-scale

0.561

High

209880

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

1

Small-scale

0.561

High

288358

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

4

High-throughput

0.553

High

701399

5HT1B
5-hydroxytryptamine receptor 1B

2

1

High-throughput

0.553

High

773754

NKAP1
Uncharacterized protein NKAPD1

2

2

High-throughput

0.553

High

297295

RGS9
Regulator of G-protein signaling 9

1

5

Small-scale

0.552

High

689806

CD27
CD27 antigen

1

0

High-throughput

0.549

High

711690

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.549

High

721469

GSTT1
Glutathione S-transferase theta-1

1

0

High-throughput

0.549

High

773711

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.549

High

773713

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.549

High

773727

CRADD
Death domain-containing protein CRADD

1

0

High-throughput

0.549

High

773755

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.549

High

773780

TOLIP
Toll-interacting protein

1

0

High-throughput

0.549

High

297336

DYSF
Dysferlin

1

0

High-throughput

0.543

High

279291

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

415388

HSPB1
Heat shock protein beta-1

1

10

High-throughput

0.541

High

773714

TSC2
Tuberin

1

1

High-throughput

0.541

High

773716

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

773717

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

3

High-throughput

0.541

High

773768

TSC1
Hamartin

1

20

High-throughput

0.541

High

773795

MYOTI
Myotilin

1

14

High-throughput

0.541

High

563326

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

773797

HSPB8
Heat shock protein beta-8

1

10

High-throughput

0.536

High

773776

ERBIN
Erbin

1

8

Small-scale

0.527

High

773761

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

9

High-throughput

0.523

High

773765

DYT2B
Dynein light chain Tctex-type protein 2B

1

2

High-throughput

0.523

High

773766

CLC4D
C-type lectin domain family 4 member D

1

7

High-throughput

0.523

High

773709

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.518

High

773798

DP13A
DCC-interacting protein 13-alpha

1

0

High-throughput

0.518

High

773745

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.515

High

648101

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.513

High

184690

ATX7
Ataxin-7

1

7

High-throughput

0.508

High

773778

ATX2
Ataxin-2

1

5

High-throughput

0.508

High

773777

NEB2
Neurabin-2

1

20

Small-scale

0.501

High

773801

SYNP2
Synaptopodin-2

1

20

Small-scale

0.501

High

773775

ARX
Homeobox protein ARX

1

4

High-throughput

0.494

High

773784

AKTIP
AKT-interacting protein

1

1

High-throughput

0.494

High

773794

ZN446
Zinc finger protein 446

1

2

High-throughput

0.494

High

773796

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

High-throughput

0.494

High

773719

SUMO3
Small ubiquitin-related modifier 3

1

7

High-throughput

0.489

High

239543

MED14
Mediator of RNA polymerase II transcription subunit 14

1

1

High-throughput

0.481

High

773712

NRIP1
Nuclear receptor-interacting protein 1

1

2

High-throughput

0.481

High

773735

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

9

Small-scale

0.481

High

773737

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.481

High

773757

MYPN
Myopalladin

1

19

Small-scale

0.481

High

773769

KAT2B
Histone acetyltransferase KAT2B

1

3

High-throughput

0.481

High

136839

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

7

High-throughput

0.479

High

222767

PRC1
Protein regulator of cytokinesis 1

1

12

High-throughput

0.479

High

681276

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.479

High

690785

1433T
14-3-3 protein theta

1

12

High-throughput

0.479

High

773710

HD
Huntingtin

1

3

Small-scale

0.479

High

773729

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

9

Small-scale

0.479

High

773731

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.479

High

773734

DLG1
Disks large homolog 1

1

9

Small-scale

0.479

High

773739

SCRIB
Protein scribble homolog

1

13

Small-scale

0.479

High

773742

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

773763

ABI1
Abl interactor 1

1

5

High-throughput

0.479

High

773772

CHM4C
Charged multivesicular body protein 4c

1

16

High-throughput

0.479

High

773782

CHM4B
Charged multivesicular body protein 4b

1

16

High-throughput

0.479

High

773783

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.479

High

773785

ECT2
Protein ECT2

1

12

High-throughput

0.479

High

773789

ANLN
Anillin

1

7

High-throughput

0.479

High

773800

PSME2
Proteasome activator complex subunit 2

1

2

High-throughput

0.479

High

116921

J3KMY6
Zinc finger C2HC-type containing 1C

1

1

High-throughput

0.470

High

773708

COIL
Coilin

1

2

High-throughput

0.464

High

773736

CENPR
Centromere protein R

1

0

High-throughput

0.460

High

773750

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.460

High

773805

LRP12
Low-density lipoprotein receptor-related protein 12

1

3

Small-scale

0.457

High

773723

1433Z
14-3-3 protein zeta/delta

1

12

High-throughput

0.445

High

773733

MFGM
Lactadherin

1

3

High-throughput

0.445

High

773746

RSPO1
R-spondin-1

1

3

High-throughput

0.445

High

282926

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

7

High-throughput

0.439

High

773774

DUX5
Double homeobox protein 5

1

8

High-throughput

0.439

High

773793

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.438

High

105460

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

330708

KI20A
Kinesin-like protein KIF20A

1

16

High-throughput

0.437

High

773799

RALY
RNA-binding protein Raly

1

2

High-throughput

0.437

High

3421

A0A0S2Z4Y0
Myotilin isoform 2

1

7

High-throughput

0.417

High

228406

DUX1
Double homeobox protein 1

1

7

High-throughput

0.417

High

87351

OSCRI
SCRIB overlapping open reading frame protein

1

1

High-throughput

0.407

High

773804

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.407

High

773749

BRM1L
Breast cancer metastasis-suppressor 1-like protein

4

0

High-throughput

0.364

High

325425

RPP14
Ribonuclease P protein subunit p14

2

0

High-throughput

0.316

High

773759

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

773764

CNNM3
Metal transporter CNNM3

2

0

High-throughput

0.316

High

239014

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.299

High

431390

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

1

0

High-throughput

0.299

High

662535

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.299

High

773756

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.299

High

773803

FA50B
Protein FAM50B

1

0

High-throughput

0.299

High

773791

ST7
Suppressor of tumorigenicity 7 protein

1

0

Small-scale

0.251

Low

773730

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025