Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: PIAS4 (Q8N2W9)
E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)
Gene: PIAS4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.916

The method score is based on:

Property Details
Experiments 12727872, 22661230, 20696768, 16371476, 21988832
Identification Methods pull down, two hybrid
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PINIT~UQ_con, UQ_con~zf-MIZ
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016605 - PML body
and 4 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 158
Hs

1 510
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Dm
+ Ce
+ At
+ Sc
+ Dm
+ Sc
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024