HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: DYST (Q03001)
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
Gene: DST

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30890647
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 7570
+	Hs
		891706 ACTB_HUMAN (4-377): 0: 599: 94.12		DYST_HUMAN (1-7570): 0: 2600: 100.00
+	Hs
		513848 ACTS_HUMAN (1-377): 0: 599: 98.94		DMD_HUMAN (383-1643): 8.98e-27: 124: 11.75
+	Dm
		361167 ACT4_DROME (1-377): 0: 649: 92.57		ACTN_DROME (3594-4062): 2.01e-11: 73.6: 9.98
+	Hs
		891697 ACTB_HUMAN (4-377): 0: 599: 94.12		SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95
+	Hs
		929824 ACTG_HUMAN (4-377): 0: 599: 94.39		SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95
+	Hs
		932107 ACTC_HUMAN (1-377): 0: 599: 100.00		SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95
+	Hs
		892113 ACTB_HUMAN (4-377): 0: 599: 94.12		MACF1_HUMAN (351-1936): 4.95e-21: 105: 11.05
+	Hs
		164588 ACTB_HUMAN (4-377): 0: 599: 94.12		SPTN2_HUMAN (5708-7163): 4.91e-17: 92.5: 14.91
+	Hs
		809100 ACTC_HUMAN (1-377): 0: 599: 100.00		UTRN_HUMAN (264-1530): 1.26e-14: 84.8: 9.65
+	Hs
		891755 ACTB_HUMAN (4-377): 0: 599: 94.12		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		929856 ACTG_HUMAN (4-377): 0: 599: 94.39		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		932145 ACTC_HUMAN (1-377): 0: 599: 100.00		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		932975 ACTS_HUMAN (1-377): 0: 599: 98.94		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		932288 ACTC_HUMAN (1-377): 0: 599: 100.00		SYNE2_HUMAN (282-1774): 1.65e-12: 77.9: 8.82
+	Hs
		929869 ACTG_HUMAN (4-377): 0: 599: 94.39		PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19
+	Hs
		932171 ACTC_HUMAN (1-377): 0: 599: 100.00		PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19
+	Hs
		932157 ACTC_HUMAN (1-377): 0: 599: 100.00		GOGB1_HUMAN (1119-1866): 1.3e-10: 71.3: 6.59
+	Hs
		506816 ACTB_HUMAN (4-377): 0: 599: 94.12		SPTB1_HUMAN (3189-4877): 1.07e-09: 68.2: 8.03
+	Dm
		284844 ACT1_DROME (1-377): 0: 598: 94.43		O77291_DROME (5467-6003): 8.81e-09: 65.1: 20.07
+	Mm
		930101 ACTH_MOUSE (4-377): 0: 591: 98.93		PLEC_MOUSE (1552-1868): 1.11e-10: 71.6: 21.56