HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: SCNNB (Q9WU38)
Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: Scnn1b

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.50	0.594

Property	Details
Experiments	12424229, 17544362, 15123669
Identification Methods	far western blotting, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 638
+	Mm
		1208291 NED4L_MOUSE (1-835): 0: 951: 97.54		SCNNB_MOUSE (1-638): 0: 727: 100.00
+	Hs
		845978 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNB_HUMAN (1-638): 0: 719: 83.91
+	Hs
		808049 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNNB_HUMAN (1-638): 0: 719: 83.91
+	Mm
		93286 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNNG_MOUSE (16-623): 0: 589: 35.71
+	Mm
		93272 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNNA_MOUSE (21-637): 0: 585: 32.44
+	Hs
		739604 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		845991 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNG_HUMAN (19-624): 0: 591: 35.43
+	Hs
		739582 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		808050 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNNG_HUMAN (19-624): 0: 591: 35.43
+	Rn
		739630 Q4V8H7_RAT (34-832): 0: 762: 36.59		SCNNG_RAT (16-623): 0: 596: 36.00
+	Hs
		739597 HUWE1_HUMAN (286-833): 3.77e-170: 548: 34.17		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		125256 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCNNB_HUMAN (1-638): 0: 719: 83.91
+	Mm
		808382 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCNNB_MOUSE (1-638): 0: 727: 100.00
+	Hs
		845975 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		SCNNB_HUMAN (1-638): 0: 719: 83.91
+	Hs
		739608 WWP1_HUMAN (6-182): 1.18e-28: 125: 22.28		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		125197 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		125257 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCNNG_HUMAN (19-624): 0: 591: 35.43
+	Hs
		739596 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Mm
		808383 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCNNG_MOUSE (16-623): 0: 589: 35.71
+	Mm
		808356 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCNNA_MOUSE (21-637): 0: 585: 32.44