HitPredict

Interactor 1: TERA (P55072)
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene: VCP

Interactor 2: UBXN4 (Q92575)
UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)
Gene: UBXN4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	19822669, 25078495, 29540532, 29997244, 35271311, 37071682, 26389662, 18775313, 16968747
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology, fluorescent resonance energy transfer, cross-linking study, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDC48_2~UBX, CDC48_N~UBX
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0036503 - ERAD pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 508
+	Ce
		759758 TERA1_CAEEL (3-796): 0: 727: 77.13		UBXN4_CAEEL (1-508): 2.99e-111: 339: 24.47
+	Hs
		320649 TERA_HUMAN (1-806): 0: 774: 100.00		UBXN7_HUMAN (2-397): 7.49e-87: 277: 15.33
+	Hs
		935098 TERA_HUMAN (1-806): 0: 774: 100.00		ASPC1_HUMAN (89-457): 9.29e-51: 183: 15.82
+	Sc
		679621 CDC48_YEAST (2-806): 0: 740: 67.75		UBX7_YEAST (172-506): 3.06e-63: 214: 20.49
+	Hs
		935292 TERA_HUMAN (1-806): 0: 774: 100.00		FAF1_HUMAN (171-397): 3.43e-47: 175: 19.38
+	Mm
		931739 TERA_MOUSE (1-806): 0: 774: 100.00		FAF1_MOUSE (171-397): 9.61e-47: 174: 19.82
+	Hs
		934980 TERA_HUMAN (1-806): 0: 774: 100.00		FAF2_HUMAN (89-394): 5.42e-45: 165: 11.18
+	Mm
		1033493 TERA_MOUSE (1-806): 0: 774: 100.00		UBXN1_MOUSE (85-396): 5.85e-46: 164: 22.96
+	Hs
		934497 TERA_HUMAN (1-806): 0: 774: 100.00		UBXN1_HUMAN (85-396): 4.22e-44: 159: 22.64
+	At
		70700 CD48A_ARATH (3-788): 0: 743: 77.16		A8MRM0_ARATH (2-212): 7.21e-50: 179: 14.73
+	At
		930111 CD48A_ARATH (3-788): 0: 743: 77.16		PUX7_ARATH (2-212): 1.5e-49: 178: 14.73
+	Hs
		122607 TERA_HUMAN (1-806): 0: 774: 100.00		UBXN8_HUMAN (203-398): 1.29e-35: 135: 15.82
+	Dm
		1266450 TERA_DROME (5-806): 0: 760: 83.09		Q7K4I5_DROME (2-158): 5.26e-38: 147: 18.35
+	Sc
		679828 CDC48_YEAST (2-806): 0: 740: 67.75		UBX6_YEAST (266-461): 2.25e-43: 160: 21.11
+	Ce
		932438 TERA1_CAEEL (3-796): 0: 727: 77.13		UBXN1_CAEEL (85-393): 9.25e-49: 171: 21.32
+	Rn
		505016 TERA_RAT (1-806): 0: 775: 99.88		UBX2B_RAT (233-395): 6.21e-24: 104: 19.54
+	Hs
		934623 TERA_HUMAN (1-806): 0: 774: 100.00		UBX2B_HUMAN (233-395): 2.63e-22: 99.7: 18.97
+	At
		930109 CD48A_ARATH (3-788): 0: 743: 77.16		PUX5_ARATH (90-391): 1.13e-20: 96.2: 12.87
+	Sp
		267770 CDC48_SCHPO (9-806): 0: 725: 70.71		UCP10_SCHPO (230-394): 3.27e-18: 88.9: 12.17
+	Sp
		152666 CDC48_SCHPO (9-806): 0: 725: 70.71		UBX2_SCHPO (7-213): 3.44e-17: 85.8: 14.62