Protein: UBXN8
UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6)

Gene: UBXN8
Organism: Homo sapiens
Interactions: 87
UniProt ID: O00124

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

122607

TERA
Transitional endoplasmic reticulum ATPase

6

16

Small-scale

0.957

High

122632

TBC15
TBC1 domain family member 15

4

2

High-throughput

0.630

High

122621

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

3

High-throughput

0.606

High

122608

SC61B
Protein transport protein Sec61 subunit beta

2

2

High-throughput

0.584

High

122576

PGRC2
Membrane-associated progesterone receptor component 2

2

0

High-throughput

0.580

High

122598

S15A1
Solute carrier family 15 member 1

2

3

High-throughput

0.574

High

122655

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

1

High-throughput

0.574

High

122600

CXA8
Gap junction alpha-8 protein

2

5

High-throughput

0.553

High

122606

VMAT1
Chromaffin granule amine transporter

1

1

High-throughput

0.536

High

122629

NPL4
Nuclear protein localization protein 4 homolog

1

5

High-throughput

0.536

High

122630

S7A14
Solute carrier family 7 member 14

1

1

High-throughput

0.536

High

122635

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

5

High-throughput

0.536

High

122636

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

8

High-throughput

0.536

High

122640

SELS
Selenoprotein S

1

1

High-throughput

0.536

High

122625

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

122633

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

122577

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

122595

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.489

High

122599

GPR12
G-protein coupled receptor 12

1

1

High-throughput

0.489

High

122611

VMAT2
Synaptic vesicular amine transporter

1

1

High-throughput

0.489

High

122619

NIPA3
Magnesium transporter NIPA3

1

3

High-throughput

0.489

High

122638

VCIP1
Deubiquitinating protein VCPIP1

1

3

High-throughput

0.489

High

122659

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

122575

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

8

High-throughput

0.479

High

122579

BAF
Barrier-to-autointegration factor

1

1

High-throughput

0.479

High

122580

RASN
GTPase NRas

1

11

High-throughput

0.479

High

122581

RASK
GTPase KRas

1

11

High-throughput

0.479

High

122582

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

122583

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

3

High-throughput

0.479

High

122596

MSH2
DNA mismatch repair protein Msh2

1

2

High-throughput

0.479

High

122597

SSRA
Translocon-associated protein subunit alpha

1

2

High-throughput

0.479

High

122603

EMD
Emerin

1

2

High-throughput

0.479

High

122605

BAP31
B-cell receptor-associated protein 31

1

2

High-throughput

0.479

High

122609

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.479

High

122612

CKAP4
Cytoskeleton-associated protein 4

1

5

High-throughput

0.479

High

122615

STIM1
Stromal interaction molecule 1

1

2

High-throughput

0.479

High

122618

RHBD2
Rhomboid domain-containing protein 2

1

5

High-throughput

0.479

High

122622

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

17

Small-scale

0.479

High

122624

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

122628

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

122634

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

3

High-throughput

0.479

High

122637

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

122639

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

122641

DERL1
Derlin-1

1

5

High-throughput

0.479

High

122643

DJC25
DnaJ homolog subfamily C member 25

1

7

High-throughput

0.479

High

122644

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

122646

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

122647

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

122657

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

122588

GFAP
Glial fibrillary acidic protein

1

3

High-throughput

0.470

High

122617

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.470

High

122660

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.460

High

122578

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.458

High

122587

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.458

High

122602

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.439

High

122585

LAMP1
Lysosome-associated membrane glycoprotein 1

1

6

High-throughput

0.437

High

122586

ADT1
ADP/ATP translocase 1

1

2

High-throughput

0.437

High

122590

ATP4A
Potassium-transporting ATPase alpha chain 1

1

7

High-throughput

0.437

High

122592

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.437

High

122593

CTR1
High affinity cationic amino acid transporter 1

1

1

High-throughput

0.437

High

122604

RAB7A
Ras-related protein Rab-7a

1

8

High-throughput

0.437

High

122610

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

1

High-throughput

0.437

High

122613

ELAV2
ELAV-like protein 2

1

2

High-throughput

0.437

High

122623

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.437

High

122626

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.437

High

122648

TBC17
TBC1 domain family member 17

1

2

High-throughput

0.437

High

122651

PXMP2
Peroxisomal membrane protein 2

1

3

High-throughput

0.437

High

122652

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.437

High

122654

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.437

High

122656

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

2

High-throughput

0.437

High

122658

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

7

High-throughput

0.437

High

122661

MTCH2
Mitochondrial carrier homolog 2

1

8

High-throughput

0.437

High

122589

VINC
Vinculin

1

2

High-throughput

0.407

High

122594

EAA2
Excitatory amino acid transporter 2

1

1

High-throughput

0.407

High

122616

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

122620

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.407

High

122631

S35G2
Solute carrier family 35 member G2

1

1

High-throughput

0.407

High

122614

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

122653

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

122627

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

122650

NCKX3
Sodium/potassium/calcium exchanger 3

1

0

High-throughput

0.279

Low

122584

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

122645

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.249

Low

122649

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.249

Low

122591

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

0

High-throughput

0.232

Low

122601

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.232

Low

122642

S13A1
Solute carrier family 13 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025