HitPredict

Interactor 1: PLXA1 (P70206)
Plexin-A1 (Plex 1) (Plexin-1)
Gene: Plxna1

Interactor 2: NRP1 (P97333)
Neuropilin-1 (A5 protein) (CD antigen CD304)
Gene: NRP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	10520994, 22522930
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CUB~Sema
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0017154 - semaphorin receptor activity GO:0021828 - gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0060666 - dichotomous subdivision of terminal units involved in salivary gland branching
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1894 Mm			1 923
+	Hs
		155470 PLXA1_HUMAN (1-1894): 0: 2608: 96.04		NRP1_HUMAN (1-923): 0: 1064: 93.17
+	Mm
		936307 PLXA2_MOUSE (14-1894): 0: 2440: 62.88		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Hs
		234447 PLXA1_HUMAN (1-1894): 0: 2608: 96.04		NRP2_HUMAN (5-923): 0: 913: 44.14
+	Mm
		192662 PLXA1_MOUSE (1-1894): 0: 2622: 100.00		NRP2_MOUSE (5-923): 0: 898: 44.10
+	Hs
		155219 PLXA2_HUMAN (36-1894): 0: 2420: 63.46		NRP1_HUMAN (1-923): 0: 1064: 93.17
+	Mm
		956242 PLXD1_MOUSE (38-1891): 0: 1887: 31.91		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Hs
		155485 PLXD1_HUMAN (38-1891): 0: 1862: 31.52		NRP1_HUMAN (1-923): 0: 1064: 93.17
+	Mm
		956250 SEM3D_MOUSE (5-541): 7.56e-136: 445: 15.19		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Mm
		140339 SEM4D_MOUSE (1-563): 1.3e-130: 433: 18.21		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Mm
		956241 Q0VGP2_MOUSE (14-543): 2e-129: 426: 19.42		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Mm
		956247 SEM4C_MOUSE (8-583): 2.05e-128: 426: 16.77		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Mm
		139667 SEM3A_MOUSE (44-541): 1.29e-128: 424: 15.19		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Mm
		956245 SEM4B_MOUSE (27-617): 7.62e-128: 424: 18.21		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Mm
		292032 SEM3F_MOUSE (12-547): 6.35e-125: 414: 16.69		NRP1_MOUSE (1-923): 0: 1085: 100.00
+	Hs
		155353 SEM3A_HUMAN (44-541): 6.22e-129: 425: 15.71		NRP1_HUMAN (1-923): 0: 1064: 93.17
+	Hs
		234430 SEM3F_HUMAN (12-547): 4.33e-125: 415: 16.47		NRP2_HUMAN (5-923): 0: 913: 44.14
+	Mm
		192664 Q0VGP2_MOUSE (14-543): 2e-129: 426: 19.42		NRP2_MOUSE (5-923): 0: 898: 44.10
+	Mm
		139663 SEM3A_MOUSE (44-541): 1.29e-128: 424: 15.19		NRP2_MOUSE (5-923): 0: 898: 44.10
+	Mm
		192667 SEM4B_MOUSE (27-617): 7.62e-128: 424: 18.21		NRP2_MOUSE (5-923): 0: 898: 44.10
+	Mm
		192660 SEM3F_MOUSE (12-547): 6.35e-125: 414: 16.69		NRP2_MOUSE (5-923): 0: 898: 44.10