HitPredict

Interactor 1: VASP (P70460)
Vasodilator-stimulated phosphoprotein (VASP)
Gene: VASP

Interactor 2: PROF2 (Q9JJV2)
Profilin-2 (Profilin II)
Gene: Pfn2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	11034907, 16319076
Identification Methods	pull down, affinity chromatography technology, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0030036 - actin cytoskeleton organization GO:0030838 - positive regulation of actin filament polymerization
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 375 Mm			1 140
+	Hs
		714941 VASP_HUMAN (1-375): 6.42e-94: 287: 87.37		PROF2_HUMAN (1-140): 3.91e-76: 224: 99.29
+	Hs
		430098 VASP_HUMAN (1-375): 6.42e-94: 287: 87.37		PROF1_HUMAN (1-140): 6.4e-76: 223: 61.43
+	Hs
		715013 EVL_HUMAN (1-370): 3.7e-83: 261: 41.93		PROF2_HUMAN (1-140): 3.91e-76: 224: 99.29
+	Hs
		430372 EVL_HUMAN (1-370): 3.7e-83: 261: 41.93		PROF1_HUMAN (1-140): 6.4e-76: 223: 61.43
+	Mm
		975407 ENAH_MOUSE (103-374): 2.59e-25: 109: 32.01		PROF2_MOUSE (1-140): 4.55e-76: 224: 100.00
+	Hs
		714977 ENAH_HUMAN (103-374): 5.17e-25: 108: 28.70		PROF2_HUMAN (1-140): 3.91e-76: 224: 99.29
+	Hs
		430264 ENAH_HUMAN (103-374): 5.17e-25: 108: 28.70		PROF1_HUMAN (1-140): 6.4e-76: 223: 61.43
+	Mm
		923919 ENAH_MOUSE (103-374): 2.59e-25: 109: 32.01		PROF1_MOUSE (1-140): 2.28e-75: 222: 62.86