HitPredict

Interactor 1: WNT3A (P56704)
Protein Wnt-3a
Gene: WNT3A

Interactor 2: WLS (Q5T9L3)
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)
Gene: WLS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.883

Property	Details
Experiments	33961781, 24768165, 22784633, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, fluorescence microscopy
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WLS-like_TM~wnt, WLS_GOLD~wnt
Common GO terms	GO:0005886 - plasma membrane GO:0030666 - endocytic vesicle membrane GO:0031901 - early endosome membrane GO:0070062 - extracellular exosome GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 541
+	Mm
		605279 WNT3_MOUSE (12-352): 8.18e-180: 503: 85.92		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		1214910 WNT5B_HUMAN (12-352): 7.66e-153: 435: 45.35		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		652165 WNT5A_MOUSE (10-352): 7.44e-152: 434: 43.86		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		833469 WNT5A_HUMAN (7-352): 2.87e-152: 435: 43.49		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		409208 WNT1_MOUSE (23-351): 4.87e-148: 424: 45.10		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		942182 WNT4_HUMAN (18-352): 6.35e-149: 425: 47.93		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		411162 WNT1_HUMAN (23-351): 3.87e-148: 424: 45.10		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		942202 WNT7B_HUMAN (26-352): 1.6e-148: 424: 45.29		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		483676 WNT2_HUMAN (21-352): 1.2e-147: 422: 43.16		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		144099 WNT7A_HUMAN (11-352): 1.44e-146: 419: 42.15		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1214923 WNT16_HUMAN (22-352): 2.83e-132: 383: 41.91		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		143741 WN10B_HUMAN (41-352): 1.56e-124: 365: 38.00		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1214909 WNT8A_HUMAN (57-351): 4.19e-124: 362: 39.47		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		167480 WNT9B_HUMAN (25-352): 2.2e-121: 355: 32.23		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		167452 WNT9A_HUMAN (42-352): 1.69e-116: 343: 33.02		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1214889 WNT8B_HUMAN (57-351): 2e-111: 330: 38.94		WLS_HUMAN (1-541): 0: 811: 100.00
+	Dm
		703410 WNT2_DROME (37-352): 1.37e-125: 366: 46.51		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		827126 WNT4_DROME (32-352): 1.88e-107: 326: 31.90		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		1378051 Q9VM25_DROME (42-335): 1.16e-96: 297: 31.46		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		703422 WNT5_DROME (28-178): 4.01e-49: 178: 37.42		WLS_DROME (1-535): 0: 642: 40.82