HitPredict

Interactor 1: GTF2I (P78347)
General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)
Gene: GTF2I

Interactor 2: KLF5 (Q13887)
Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)
Gene: KLF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35140242
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 998 Hs			1 457
+	Hs
		316854 GTF2I_HUMAN (1-998): 0: 1555: 100.00		KLF8_HUMAN (366-455): 4.48e-40: 149: 78.89
+	Hs
		942276 GTF2I_HUMAN (1-998): 0: 1555: 100.00		KLF15_HUMAN (364-456): 2.03e-32: 129: 64.52
+	Hs
		942241 GTF2I_HUMAN (1-998): 0: 1555: 100.00		KLF16_HUMAN (373-455): 1.97e-30: 120: 63.86
+	Hs
		563776 GTF2I_HUMAN (1-998): 0: 1555: 100.00		ZNF3_HUMAN (86-378): 7.41e-29: 119: 10.81
+	Hs
		563548 GT2D1_HUMAN (571-975): 2.18e-31: 134: 23.30		ZNF23_HUMAN (22-293): 1.01e-65: 224: 7.27