Protein: WLS
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)

Gene: WLS
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q5T9L3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001707 - mesoderm formation
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

942182

WNT4
Protein Wnt-4

4

20

High-throughput

0.892

High

942158

WNT3A
Protein Wnt-3a

4

20

Small-scale

0.883

High

144099

WNT7A
Protein Wnt-7a

3

20

Small-scale

0.861

High

833469

WNT5A
Protein Wnt-5a

3

20

Small-scale

0.861

High

1214866

WLS
Protein wntless homolog

2

1

Small-scale

0.819

High

770864

OPRM
Mu-type opioid receptor

4

6

Small-scale

0.712

High

1214923

WNT16
Protein Wnt-16

1

20

High-throughput

0.691

High

1214886

5HT3C
5-hydroxytryptamine receptor 3C

3

3

High-throughput

0.667

High

477424

CD63
CD63 antigen

3

5

Small-scale

0.656

High

855331

5HT3A
5-hydroxytryptamine receptor 3A

2

4

High-throughput

0.628

High

1057547

ACHD
Acetylcholine receptor subunit delta

2

2

High-throughput

0.628

High

483676

WNT2
Protein Wnt-2

1

20

High-throughput

0.618

High

411162

WNT1
Proto-oncogene Wnt-1

1

20

Small-scale

0.618

High

942202

WNT7B
Protein Wnt-7b

1

20

Small-scale

0.618

High

1214909

WNT8A
Protein Wnt-8a

1

20

Small-scale

0.618

High

1214910

WNT5B
Protein Wnt-5b

1

20

Small-scale

0.618

High

539709

ACHB
Acetylcholine receptor subunit beta

2

2

High-throughput

0.601

High

709248

AA2AR
Adenosine receptor A2a

2

2

Small-scale

0.601

High

851135

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

2

1

High-throughput

0.601

High

1214926

CLC4E
C-type lectin domain family 4 member E

2

0

High-throughput

0.595

High

1033929

SC6A3
Sodium-dependent dopamine transporter

2

0

Small-scale

0.585

High

375596

RASK
GTPase KRas

2

4

High-throughput

0.584

High

978068

RHOB
Rho-related GTP-binding protein RhoB

2

2

High-throughput

0.584

High

1168733

DOXA2
Dual oxidase maturation factor 2

2

0

High-throughput

0.576

High

1142847

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

Small-scale

0.575

High

143741

WN10B
Protein Wnt-10b

1

20

High-throughput

0.575

High

317069

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

2

0

Small-scale

0.559

High

936147

AQP4
Aquaporin-4

2

0

Small-scale

0.559

High

1214874

PIGW
Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

2

0

Small-scale

0.559

High

1214890

TM230
Transmembrane protein 230

2

0

Small-scale

0.559

High

1214897

YIPF6
Protein YIPF6

2

0

Small-scale

0.559

High

1214915

TM134
Transmembrane protein 134

2

0

Small-scale

0.559

High

1214916

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

2

0

Small-scale

0.559

High

1214920

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

0

Small-scale

0.559

High

1214921

CNIH4
Protein cornichon homolog 4

2

0

Small-scale

0.559

High

1214927

PCDBA
Protocadherin beta-10

2

0

Small-scale

0.559

High

1214931

TM14A
Transmembrane protein 14A

2

0

Small-scale

0.559

High

167452

WNT9A
Protein Wnt-9a

1

20

Small-scale

0.553

High

167480

WNT9B
Protein Wnt-9b

1

20

Small-scale

0.553

High

1214889

WNT8B
Protein Wnt-8b

1

20

Small-scale

0.553

High

1214876

S22A9
Organic anion transporter 7

2

5

High-throughput

0.549

High

186915

GPR37
Prosaposin receptor GPR37

1

4

High-throughput

0.541

High

572446

DRD2
D(2) dopamine receptor

1

2

High-throughput

0.541

High

770801

HRH1
Histamine H1 receptor

1

6

High-throughput

0.541

High

835485

CCR2
C-C chemokine receptor type 2

1

5

High-throughput

0.541

High

165952

FFAR1
Free fatty acid receptor 1

1

6

High-throughput

0.536

High

182570

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.536

High

553426

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

1

High-throughput

0.536

High

761085

GBRA3
Gamma-aminobutyric acid receptor subunit alpha-3

1

1

High-throughput

0.536

High

1214885

TMED6
Transmembrane emp24 domain-containing protein 6

1

1

High-throughput

0.536

High

1214930

SNX8
Sorting nexin-8

1

1

High-throughput

0.536

High

1214902

SMO
Protein smoothened

1

0

High-throughput

0.518

High

832385

OPRK
Kappa-type opioid receptor

1

5

Small-scale

0.515

High

698752

CALX
Calnexin

1

0

High-throughput

0.513

High

732996

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.513

High

888890

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

1214869

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.513

High

1214879

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

1214887

NICA
Nicastrin

1

0

High-throughput

0.513

High

1214914

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

1214904

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

1

Small-scale

0.506

High

1214917

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.493

High

906894

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

Small-scale

0.484

High

178287

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

373981

RASN
GTPase NRas

1

4

High-throughput

0.479

High

374667

RASH
GTPase HRas

1

2

High-throughput

0.479

High

466302

RHOC
Rho-related GTP-binding protein RhoC

1

2

High-throughput

0.479

High

630830

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.479

High

631273

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

832368

OPRD
Delta-type opioid receptor

1

5

Small-scale

0.479

High

845675

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

900858

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.479

High

901860

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

956334

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

962144

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

1214880

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

1214884

RN128
E3 ubiquitin-protein ligase RNF128

1

1

High-throughput

0.479

High

1214888

UBXN4
UBX domain-containing protein 4

1

1

Small-scale

0.479

High

1214894

FAF2
FAS-associated factor 2

1

1

Small-scale

0.479

High

173951

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

218294

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

321263

ERLN2
Erlin-2

1

0

Small-scale

0.458

High

417490

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418194

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

487407

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

820666

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

884116

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.458

High

934721

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

951201

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

975079

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1087144

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

1113331

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1144946

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1214868

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1214872

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1214875

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1214877

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.458

High

1214891

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1214899

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1214900

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1214901

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.458

High

1214906

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1214911

PORCN
Protein-serine O-palmitoleoyltransferase porcupine

1

0

Small-scale

0.458

High

1214912

GOLP3
Golgi phosphoprotein 3

1

0

Small-scale

0.458

High

1214922

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.458

High

1214928

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.458

High

622061

CD53
Leukocyte surface antigen CD53

1

5

High-throughput

0.445

High

1199078

CTL4
Choline transporter-like protein 4

1

1

High-throughput

0.445

High

1214878

S22AO
Steroid transmembrane transporter SLC22A24

1

5

High-throughput

0.445

High

1214881

CTL5
Choline transporter-like protein 5

1

1

High-throughput

0.445

High

1214907

S22A4
Solute carrier family 22 member 4

1

5

High-throughput

0.445

High

1214924

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

1

High-throughput

0.445

High

1214929

S22AE
Solute carrier family 22 member 14

1

5

High-throughput

0.445

High

354458

PX11B
Peroxisomal membrane protein 11B

1

0

Small-scale

0.438

High

571613

IRF2
Interferon regulatory factor 2

1

0

Small-scale

0.438

High

640917

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

Small-scale

0.438

High

1030736

CAP1
Adenylyl cyclase-associated protein 1

1

0

Small-scale

0.438

High

1214873

ALKMO
Alkylglycerol monooxygenase

1

0

Small-scale

0.438

High

1214883

KMT2C
Histone-lysine N-methyltransferase 2C

1

0

Small-scale

0.438

High

1214896

ORAI1
Calcium release-activated calcium channel protein 1

1

0

Small-scale

0.438

High

1214913

RNF41
E3 ubiquitin-protein ligase NRDP1

1

0

Small-scale

0.438

High

1214870

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1214898

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

704020

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.426

High

1199500

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1214882

ZNT7
Zinc transporter 7

1

0

High-throughput

0.426

High

1214908

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

1214867

S22AA
Solute carrier family 22 member 10

1

5

High-throughput

0.407

High

1214871

S22AP
Solute carrier family 22 member 25

1

5

High-throughput

0.407

High

1214895

F241B
Protein FAM241B

2

0

Small-scale

0.313

High

873092

SOX9
Transcription factor SOX-9

2

0

Small-scale

0.304

High

1213739

ZFAS1
Uncharacterized protein ZNF22-AS1

2

0

Small-scale

0.304

High

1214893

TOM6
Mitochondrial import receptor subunit TOM6 homolog

2

0

Small-scale

0.304

High

1214919

TM160
Transmembrane protein 160

2

0

Small-scale

0.304

High

1214918

RPRM
Protein reprimo

1

0

High-throughput

0.279

Low

1214892

BORC7
BLOC-1-related complex subunit 7

1

0

Small-scale

0.257

Low

1214905

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.249

Low

1214903

CG025
UPF0415 protein C7orf25

1

0

Small-scale

0.238

Low

1214925

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025