HitPredict

Interactor 1: JAG1 (P78504)
Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
Gene: JAG1

Interactor 2: MIB1 (Q86YT6)
E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2)
Gene: MIB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25747658, 20720151
Identification Methods	x-ray crystallography, affinity chromatography technology, pull down, enzymatic study
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007219 - Notch signaling pathway GO:0045665 - negative regulation of neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1218 Hs			1 1006
+	Mm
		1193398 JAG1_MOUSE (1-1218): 0: 686: 96.55		MIB1_MOUSE (1-1006): 0: 870: 99.30
+	Mm
		1193399 JAG2_MOUSE (25-1129): 2.32e-162: 518: 54.34		MIB1_MOUSE (1-1006): 0: 870: 99.30
+	Hs
		1284699 JAG2_HUMAN (26-1132): 2.03e-162: 518: 54.42		MIB2_HUMAN (14-1006): 0: 593: 29.05
+	Hs
		132263 DLL1_HUMAN (692-1102): 5.92e-23: 107: 20.34		MIB1_HUMAN (1-1006): 0: 867: 100.00
+	Mm
		1193397 DLL4_MOUSE (650-1041): 3.48e-21: 101: 20.51		MIB1_MOUSE (1-1006): 0: 870: 99.30
+	Mm
		1142610 DLL1_MOUSE (684-1029): 1.36e-14: 80.7: 20.98		MIB1_MOUSE (1-1006): 0: 870: 99.30
+	Dr
		1193380 DLLC_DANRE (688-1046): 1.17e-15: 84.2: 18.56		MIB1_DANRE (1-1006): 0: 822: 91.47
+	Dr
		50483 A1L1P2_DANRE (67-310): 6.01e-15: 81.9: 17.74		MIB1_DANRE (1-1006): 0: 822: 91.47
+	Dm
		485029 DL_DROME (616-1104): 3.85e-23: 108: 18.76		Q9VJ14_DROME (15-1006): 0: 628: 33.02
+	Dr
		47661 DLLC_DANRE (688-1046): 1.17e-15: 84.2: 18.56		A0AR23_DANRE (8-1006): 0: 617: 29.01
+	Dr
		47638 A1L1P2_DANRE (67-310): 6.01e-15: 81.9: 17.74		A0AR23_DANRE (8-1006): 0: 617: 29.01
+	Dm
		65546 NOTCH_DROME (22-672): 1.07e-46: 186: 21.24		A8JNM5_DROME (188-996): 1.68e-153: 506: 16.57
+	Dm
		422915 NOTCH_DROME (22-672): 1.07e-46: 186: 21.24		MIB_DROME (563-1005): 5.44e-61: 229: 18.04
+	Dm
		575654 SERR_DROME (22-433): 1.19e-25: 117: 18.81		MIB_DROME (563-1005): 5.44e-61: 229: 18.04
+	Dm
		485032 DL_DROME (616-1104): 3.85e-23: 108: 18.76		MIB_DROME (563-1005): 5.44e-61: 229: 18.04
+	Hs
		166914 NOTC2_HUMAN (591-1041): 2.37e-45: 182: 24.42		ANR28_HUMAN (169-452): 1.58e-23: 109: 11.11
+	Hs
		167042 NOTC3_HUMAN (637-1062): 5.33e-38: 158: 23.71		ANR28_HUMAN (169-452): 1.58e-23: 109: 11.11
+	Hs
		980449 NOTC2_HUMAN (591-1041): 2.37e-45: 182: 24.42		ANR44_HUMAN (193-343): 4.24e-11: 69.4: 8.55
+	Hs
		804293 NOTC1_HUMAN (22-654): 1.13e-44: 179: 20.73		ANR44_HUMAN (193-343): 4.24e-11: 69.4: 8.55
+	Hs
		1237561 NOTC3_HUMAN (637-1062): 5.33e-38: 158: 23.71		ANR44_HUMAN (193-343): 4.24e-11: 69.4: 8.55