Protein: RIPK2
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)

Gene: RIPK2
Organism: Homo sapiens
Interactions: 130
UniProt ID: O43353

Gene Ontology (top 5):
GO:0001961 - positive regulation of cytokine-mediated signaling pathway
GO:0002250 - adaptive immune response
GO:0002827 - positive regulation of T-helper 1 type immune response
GO:0004674 - protein serine/threonine kinase activity
GO:0004706 - JUN kinase kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

214414

XIAP
E3 ubiquitin-protein ligase XIAP

15

20

Small-scale

0.989

High

214464

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

21

9

Small-scale

0.987

High

214357

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

9

17

Small-scale

0.970

High

214424

BIRC2
Baculoviral IAP repeat-containing protein 2

6

20

Small-scale

0.960

High

214470

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

7

10

Small-scale

0.956

High

214390

CASP1
Caspase-1

6

8

Small-scale

0.935

High

214423

BIRC3
Baculoviral IAP repeat-containing protein 3

4

17

Small-scale

0.916

High

213724

M3K7
Mitogen-activated protein kinase kinase kinase 7

4

20

Small-scale

0.894

High

214409

1433E
14-3-3 protein epsilon

2

6

Small-scale

0.806

High

214408

1433G
14-3-3 protein gamma

2

20

Small-scale

0.800

High

214437

CAR16
Caspase recruitment domain-containing protein 16

2

2

Small-scale

0.776

High

214460

CARD6
Caspase recruitment domain-containing protein 6

2

3

Small-scale

0.776

High

214378

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

Small-scale

0.768

High

214358

TLR2
Toll-like receptor 2

2

20

Small-scale

0.754

High

214400

IRAK1
Interleukin-1 receptor-associated kinase 1

2

20

Small-scale

0.754

High

214388

1433T
14-3-3 protein theta

1

20

Small-scale

0.724

High

214394

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.724

High

214474

TRAF6
TNF receptor-associated factor 6

5

20

Small-scale

0.702

High

214363

STK10
Serine/threonine-protein kinase 10

1

9

High-throughput

0.691

High

214417

1433F
14-3-3 protein eta

1

20

High-throughput

0.691

High

214462

SLK
STE20-like serine/threonine-protein kinase

1

7

High-throughput

0.691

High

214421

TRAF3
TNF receptor-associated factor 3

3

20

Small-scale

0.683

High

214459

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

2

0

High-throughput

0.679

High

214418

TRAF2
TNF receptor-associated factor 2

3

20

Small-scale

0.667

High

214404

ANM2
Protein arginine N-methyltransferase 2

1

1

High-throughput

0.656

High

214435

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

0

High-throughput

0.656

High

214475

NEMO
NF-kappa-B essential modulator

3

11

Small-scale

0.650

High

177742

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

10

Small-scale

0.647

High

214359

ULK1
Serine/threonine-protein kinase ULK1

1

5

Small-scale

0.647

High

214438

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

Small-scale

0.647

High

214425

SQSTM
Sequestosome-1

3

10

Small-scale

0.640

High

126272

TLR4
Toll-like receptor 4

1

20

Small-scale

0.618

High

214360

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

2

Small-scale

0.618

High

214367

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.618

High

214374

HS90A
Heat shock protein HSP 90-alpha

1

17

High-throughput

0.618

High

214375

TNR16
Tumor necrosis factor receptor superfamily member 16

1

10

Small-scale

0.618

High

214380

EZRI
Ezrin

1

8

High-throughput

0.618

High

214383

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

10

Small-scale

0.618

High

214395

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

214426

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

17

Small-scale

0.618

High

214443

CASPC
Inactive caspase-12

1

8

Small-scale

0.618

High

214461

CARD9
Caspase recruitment domain-containing protein 9

1

5

Small-scale

0.618

High

214467

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

7

Small-scale

0.618

High

214468

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.618

High

214477

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

8

Small-scale

0.618

High

214361

ERLN1
Erlin-1

2

1

Small-scale

0.611

High

214365

ERLN2
Erlin-2

2

2

Small-scale

0.611

High

214444

MAVS
Mitochondrial antiviral-signaling protein

1

3

High-throughput

0.597

High

214441

A16L1
Autophagy-related protein 16-1

2

4

Small-scale

0.595

High

214376

VIME
Vimentin

2

2

High-throughput

0.584

High

214432

IRF4
Interferon regulatory factor 4

2

1

Small-scale

0.584

High

214449

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

2

Small-scale

0.578

High

214452

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

2

Small-scale

0.561

High

214413

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.541

High

49984

IRGM
Immunity-related GTPase family M protein

1

0

Small-scale

0.537

High

214419

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

4

High-throughput

0.536

High

214471

STRAP
Serine-threonine kinase receptor-associated protein

1

3

High-throughput

0.536

High

214476

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

4

High-throughput

0.536

High

192973

CFLAR
CASP8 and FADD-like apoptosis regulator

1

7

Small-scale

0.515

High

214420

TRAF1
TNF receptor-associated factor 1

1

20

Small-scale

0.515

High

214434

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

5

Small-scale

0.515

High

214465

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.515

High

63911

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

214445

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.513

High

214455

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.513

High

214410

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.493

High

214411

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.493

High

214453

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

High-throughput

0.493

High

214456

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

214473

KDM3A
Lysine-specific demethylase 3A

1

0

High-throughput

0.486

High

214407

GMFB
Glia maturation factor beta

1

0

High-throughput

0.481

High

214429

BECN1
Beclin-1

1

0

Small-scale

0.480

High

136646

TRAF5
TNF receptor-associated factor 5

1

20

Small-scale

0.479

High

165208

PSA7
Proteasome subunit alpha type-7

1

2

High-throughput

0.479

High

214364

MYO1D
Unconventional myosin-Id

1

7

High-throughput

0.479

High

214369

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.479

High

214373

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

214377

CLCA
Clathrin light chain A

1

1

High-throughput

0.479

High

214379

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.479

High

214381

HSP76
Heat shock 70 kDa protein 6

1

12

High-throughput

0.479

High

214382

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

2

Small-scale

0.479

High

214385

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

5

High-throughput

0.479

High

214387

TNR5
Tumor necrosis factor receptor superfamily member 5

1

10

Small-scale

0.479

High

214389

PSB5
Proteasome subunit beta type-5

1

2

High-throughput

0.479

High

214396

HS71L
Heat shock 70 kDa protein 1-like

1

12

High-throughput

0.479

High

214397

MYH9
Myosin-9

1

2

High-throughput

0.479

High

214398

MYH10
Myosin-10

1

2

High-throughput

0.479

High

214399

PERI
Peripherin

1

2

High-throughput

0.479

High

214402

HSP72
Heat shock-related 70 kDa protein 2

1

12

High-throughput

0.479

High

214403

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

4

High-throughput

0.479

High

214406

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.479

High

214412

ACTG
Actin, cytoplasmic 2

1

4

High-throughput

0.479

High

214415

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

214416

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

214422

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

3

High-throughput

0.479

High

214427

CUL3
Cullin-3

1

2

High-throughput

0.479

High

214428

TRI14
Tripartite motif-containing protein 14

1

7

High-throughput

0.479

High

214430

NBR1
Next to BRCA1 gene 1 protein

1

2

Small-scale

0.479

High

214446

NLRX1
NLR family member X1

1

7

High-throughput

0.479

High

214447

TCAM1
TIR domain-containing adapter molecule 1

1

4

Small-scale

0.479

High

214454

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

Small-scale

0.479

High

214457

TRAF4
TNF receptor-associated factor 4

1

20

Small-scale

0.479

High

214458

TBB2B
Tubulin beta-2B chain

1

20

High-throughput

0.479

High

214469

Q9UQC1
Heat shock protein 72

1

15

High-throughput

0.479

High

214366

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

214370

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

214372

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

214386

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.458

High

214391

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

214405

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

214431

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

214433

TRIP6
Thyroid receptor-interacting protein 6

1

0

Small-scale

0.458

High

214442

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.458

High

214448

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.458

High

214451

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

214472

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

214362

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.445

High

214463

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

4

High-throughput

0.445

High

214393

ECHM
Enoyl-CoA hydratase, mitochondrial

1

5

High-throughput

0.437

High

214401

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

1

High-throughput

0.437

High

214440

OTUD1
OTU domain-containing protein 1

1

4

Small-scale

0.437

High

214466

Q9NZ23
glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.437

High

214371

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.426

High

214439

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.279

Low

214368

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.249

Low

214392

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.249

Low

214436

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.249

Low

214450

NAT16
Probable N-acetyltransferase 16

1

0

Small-scale

0.249

Low

214384

KLK2
Kallikrein-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025