HitPredict

Interactor 1: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Interactor 2: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 1.00 0.820

The method score is based on:

Property Details
Experiments 10608806, 10464290, 24220101
Identification Methods unspecified method, affinity chromatography technology, enzymatic study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains DNA-PKcs_N~FAT, DNA-PKcs_N~PI3_PI4_kinase, DNAPKcs_CC5~FAT, DNAPKcs_CC5~PI3_PI4_kinase, FAT~FAT, FAT~FATC, FAT~PI3_PI4_kinase, FATC~PI3_PI4_kinase, PI3_PI4_kinase~PI3_PI4_kinase
Common GO terms GO:0000723 - telomere maintenance
GO:0001756 - somitogenesis
GO:0004674 - protein serine/threonine kinase activity
GO:0004677 - DNA-dependent protein kinase activity
GO:0005524 - ATP binding
and 16 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 4128
Hs

1 3056
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Last updated: 15 Jul 2024