HitPredict

Interactor 1: P79947 (P79947)
Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
Gene: smad1.S

Interactor 2: SMUF1 (Q9PUN2)
E3 ubiquitin-protein ligase SMURF1 (xSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: smurf1

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10458166
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030154 - cell differentiation GO:0030509 - BMP signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Xl			1 731
+	Mm
		936618 SMAD1_MOUSE (1-464): 0: 662: 94.41		SMUF1_MOUSE (1-731): 0: 800: 90.16
+	Hs
		1078761 SMAD1_HUMAN (1-464): 0: 663: 94.62		SMUF1_HUMAN (1-731): 0: 798: 87.60
+	Hs
		1305888 SMAD5_HUMAN (2-464): 0: 638: 89.66		SMUF1_HUMAN (1-731): 0: 798: 87.60
+	Hs
		1078760 SMAD1_HUMAN (1-464): 0: 663: 94.62		SMUF2_HUMAN (1-731): 0: 765: 71.60
+	Mm
		56826 SMAD1_MOUSE (1-464): 0: 662: 94.41		SMUF2_MOUSE (1-731): 0: 766: 71.86
+	Hs
		1305886 SMAD5_HUMAN (2-464): 0: 638: 89.66		SMUF2_HUMAN (1-731): 0: 765: 71.60
+	Hs
		950291 SMAD3_HUMAN (3-464): 0: 548: 59.36		SMUF1_HUMAN (1-731): 0: 798: 87.60
+	Hs
		950287 SMAD3_HUMAN (3-464): 0: 548: 59.36		SMUF2_HUMAN (1-731): 0: 765: 71.60
+	Hs
		808135 SMAD1_HUMAN (1-464): 0: 663: 94.62		NEDD4_HUMAN (107-729): 0: 637: 37.20
+	Hs
		808240 SMAD5_HUMAN (2-464): 0: 638: 89.66		NEDD4_HUMAN (107-729): 0: 637: 37.20
+	Hs
		808087 SMAD3_HUMAN (3-464): 0: 548: 59.36		NEDD4_HUMAN (107-729): 0: 637: 37.20
+	Hs
		1078757 SMAD1_HUMAN (1-464): 0: 663: 94.62		WWP1_HUMAN (2-372): 9.32e-20: 96.4: 14.25
+	Dm
		785477 MAD_DROME (2-464): 0: 615: 73.22		SMUF1_DROME (7-263): 3.76e-28: 123: 36.19
+	Hs
		1305881 SMAD5_HUMAN (2-464): 0: 638: 89.66		WWP1_HUMAN (2-372): 9.32e-20: 96.4: 14.25
+	Hs
		1305892 SMAD5_HUMAN (2-464): 0: 638: 89.66		HECW2_HUMAN (1-232): 5.58e-13: 74.8: 16.08
+	Dm
		785516 MAD_DROME (2-464): 0: 615: 73.22		SUDX_DROME (209-407): 1.4e-14: 79.8: 17.79
+	Hs
		950249 SMAD3_HUMAN (3-464): 0: 548: 59.36		NED4L_HUMAN (6-396): 1.05e-33: 141: 13.43
+	Hs
		125369 SMAD3_HUMAN (3-464): 0: 548: 59.36		WWP2_HUMAN (1-409): 2.7e-26: 117: 15.53
+	Hs
		950248 SMAD3_HUMAN (3-464): 0: 548: 59.36		ITCH_HUMAN (1-395): 5.84e-24: 109: 15.70
+	Hs
		950278 SMAD3_HUMAN (3-464): 0: 548: 59.36		WWP1_HUMAN (2-372): 9.32e-20: 96.4: 14.25